Medical & Biotech – Page 58 – TechConnect Briefs

Novel alternative, multistranded, plasmid, and helical transitional DNA and RNA microarrays: the next generation of nucleic acid microarrays

Gagna C.E., Lambert W.C., New York Institute of Technology, US

Novel multistranded and alternative DNA, RNA and plasmid microarrays have been developed that allow for immobilization of intact, nondenatured nucleic acids. Biomolecules are anchored onto a solid support and can move freely, while researchers experiment [...]

Investigation of Zona Pellucida Hardening with Atomic Force Microscopy and Nonlinear Optimization

Frassanito M.C., Papi M., De Spirito M., Lamberti L., Boccaccio A., Arcovito G., Pappalettere C., Politecnico di Bari, IT

The Zona Pellucida (ZP) is an extracellular membrane surrounding mammalian oocytes. The so called “zona hardening” has a key role in the fertilization process as it produces a block of polyspermy also through an increase [...]

The Intracellular Co- localizations of Different Size of Gold Nanoparticles

Boyoglu C., Boyoglu-Barnum S., Boyoglu-Barnum S., Soni S., He Q., Willing G., Miller M.E., Singh S.R., Alabama State University, US

Gold nanoparticles (GNPs) are widely used in biological and clinical applications due to their favorable optical and chemical properties. The scientific understanding of the intracellular uptake of GNP is required for biomedical applications, such as [...]

The influence of magnetite nanoparticles (MCS-B) on the hemolysis of erythrocytes

Belousov A.N., Laboratory of Applied Nanotechnology, UA

In Ukraine the first medical nanotechnology drugs were synthesized and patented in 1998 (http://www.nanolab.com.ua). These are such drugs as intracorporeal biocorrector (ICBB), magnet-controlled sorbent (MCS-B) and Micromage-B (Belousov A.N., 1997, 1998, 2000). Basis of the [...]

Stable Magnetic Isotopes and Reliability of Biomolecular Nanoreactors

Koltover V.K., Institute of Problems of Chemical Physics, Russian Academy of Sciences, RU

The trend of nanoscaling brings engineering down to the dimensions of molecular structures but in so doing poses also the problem of how to create the reliable system from the molecular components which experience permanent [...]

Nanostructural Changes in Surface of Stainless Steel Archwires Combined with Orthodontic Conventional and Self-Ligating Brackets

Choi S., Joo H., Cheong Y., Lee S., Kim S., Park H.K., Park Y.-G., Park H.K., Park Y.-G., Kyung Hee University, KR

It is well-known that the frictional force between the archwire (AW) and the bracket reduces the efficiency of orthodontic treatment. It is affected not only by geometry of self-ligating brackets but also by physical changes [...]

Nanostructural Effects of Mitomycin C Applications on Scleral Collagen Fibrils: Atomic Force Microscopy Observation

Choi S., Cheong Y., Kwon E., Jung G.B., Lee H.J., Shin J.-H., Jin K.-H., Park H.K., Kyung Hee University, KR

This study was to investigate the effects of Mitomycin C on the scleral collagen surfaces by atomic force microscopy (AFM). Two non-contact mode AFM machines were used to observe changes in the morphological characteristics of [...]

Celastrol-Based Nanomedicines as Modulators of Neuroinflammation

Boridy S., Hutter E., Soliman G., Maysinger D., McGill University, CA

Chronic inflammation plays a pivotal role in promoting disease pathology in the central nervous system (CNS). Microglial cells are the main innate immune effector cells in the CNS and orchestrate these neuroinflammatory reactions that ultimately [...]

Non-invasive Lesion Imaging and Delivery of Nano-Therapeutics to the Ischemic Brain

Choi A.O., Vaisheva F., Soliman G.M., Maysinger D., McGill University, CA

Silent brain infarcts are often asymptomatic, but these micro-lesions can cause considerable neurodegenerative damage if they remain undetected and untreated. Cells undergo rapid irreversible necrosis at the ischemic core; however, viable cells in the penumbra [...]

Molar variation of water: alkoxy in the preparation of SiO2-DA materials and its effect on dopamine release from an implantable reservoir in the brain

Lopez T., Esquivel D., Garcia E., National Institute of Neurology and Neurosurgery, MX

In the present work we report the dopamine (DA) molecules stabilization in the network of nanostructured silica materials with the objective of using these as reservoirs of DA release in the brain. For this purpose [...]