Medical & Biotech – Page 43 – TechConnect Briefs

Water-borne Polymeric Nanoparticles for Glutathione-Mediated Intracellular Delivery of Anticancer Drugs

Grimaldi N., università degli studi di palermo, IT

A new family of water-borne, biocompatible and carboxyl-functionalized nanogels (NGs) was developed for glutathione-mediated delivery of anticancer drugs. Nanogels were generated by e-beam irradiation of aqueous solutions of a crosslinkable polymer. Molecular structure and topology [...]

In vivo nanotoxicology: Toxicoproteomics

Sabella S., Kote S., Pompa P.P., Italian Institute of Technology, IT

Proteomics applied to nanotechnology is now emerging as an attractive tool to address the still unanswered questions dealing with nano-biointeractions and NPs-induced toxicity in living systems. The unique advantage provided by “omic” techniques (such as, [...]

Bio Nano Materials

Real-Time Electronic Detection of Water/Food Borne Pathogens

Potter M., BiSen Tech LLC, US

Current methods for detecting water-borne pathogens require a laboratory setting, analyte preparation and typically a day or more. The author, a solid state device physicist, has invented a methodology capable of the real-time (1 - [...]

Detection of novel endocrine-disrupting chemicals in the water

Stavreva D.A., Varticovski L., Hager G.L., National Cancer Institute, US

There is a growing interest in the health risk posed by endocrine-disrupting chemicals (EDCs). Detection and monitoring of water sources for steroidal EDCs relies on a laborious analysis of their chemical structures. It is also [...]

Visual quantification of melamine using citrate-capped gold nanoparticles

Li N., University of Miami, US

Melamine is a nitrogen-rich compound widely used in plastics industry. Due to its high nitrogen content and low cost, it has been illegally added to food products to boost apparent protein content. Conventional methods to [...]

In vitro biosensing based on magnetically induced motion of magnetic nanoparticles

Dangl A., Kokkinis G., Keplinger F., Giouroudi I., Vienna University of Technology, AT

A method for in-vitro detection of bioanalyte using conductive microstructures to accelerate magnetic nanoparticles (MAPs) in an integrated microfluidic system is presented. The fundamental idea behind the elaboration of such a biosensing system is that [...]

Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (–) prostate cancers

Jo H., Ban C., Pohang University of Science and Technology, KR

We have designed a dual-aptamer complex specific to both prostate-specific membrane antigens (PSMA) (+) and (–) prostate cancer cells. In the complex, an A10 RNA aptamer targeting PSMA (+) cells ¬¬and a DUP-1 peptide aptamer [...]

Towards Wireless Implantable Pressure Sensor to Monitor Compartment Syndrome in Trauma Victims

Wang Y., Allen C., AL-Qahtani S., Merdassi A., Chodavarapu V.P., Harvey E., Henderson J., McGill Universiy, CA

We describe a simple, miniature, wireless device that can accurately measure pressure fluctuations in the limb compartments of patients at risk of developing ACS. We plan to use temporary indwelling, direct pressure sensors consisting of [...]

From Viruses to Cells: Tuneable Resistive Pulse Sensors for High Resolution Characterization of Nano to Micro-Scale Particle Solutions

Kozak D., Anderson W., Vogel R., Broom M.F., Izon Science, US

Tuneable resistive pulse sensors (TRPS) have generated considerable interest for their ability to accurately characterize the size, charge and concentration of nano to micro-scale particulate suspensions. Measuring the properties of each particle (e.g. exosome, virus, [...]