Medical & Biotech – Page 188 – TechConnect Briefs

A Fokker-Planck Approach For Modeling Integrated NanoBio Systems

Jenkins J.W., Sundaram S., CFD Research Corporation, US

Physics-based, high-fidelity simulations have emerged as indispensable tools in the design of complex, microfluidic devices (lab-on-chip). However, ab-initio analysis becomes increasingly complicated as the dimensions of the device approach nanoscales and molecular information/interactions must be [...]

Biologically Inspired Controls over Assembly of Crystalline Nanostructures

De Yoreo J.J., Orme C.A., Qiu R., Dove P.M., Lawrence Livermore National Laboratory, US

By utilizing small molecules and proteins to modulate crystal nucleation and growth, living organisms produce single nanocrystals and nanocrystal composites that exhibit control over the location, phase and crystallographic orientation of the nuclei, as well [...]

DNA base damage: A Car-Parrinello Molecular Dynamics Study of Guanine and Thymine with an OH Radical

Wu Y., Mundy C.J., Colvin M.E., Car R., Lawrence Livermore National Labs, US

Understanding the basic chemistry of radicals and DNA bases is an important step in characterizing the potential damage to DNA. The chemical level understanding of such damage has far reaching implications for radiation therapy, health [...]

Electrohydrodynamic Interactions of an AFM Tip and a Biological Membrane

Fan T.H., Fedorov A.G., Georgia Institute of Technology, US

In biological applications, AFM imaging needs to be performed in the natural (aqueous) living environment of the cell in order to observe molecular level interactions and biochemical processes in-situ in the electrolyte solution and to [...]

Bio Nano Systems and Chemistry

Nanomolecular Gravitational Interactions Causing Incrased Probability of Birth Defects in Humans During Period from Conception to Early Fetus Formation

Vezzoli G.C., The Franklin Institute of Technology, US

It is found that small decreases in gravity that are caused by planet syzygy, full moon presence, and cosmogonic events of deep space can cause a sufficient change in gravitational interactions to affect the nucleons [...]

11-cis-Retinal Protonated Schiff Base: The effect of environment and solvent on the chromophore of rhodopsin

Entel P., Sugihara M., Buß V., Elstner M., Frauenheim Th., Gerhard-Mercator-Universität, DE

Recently the structure of rhodopsin was determined from the X-ray diffraction data extending to the resolution of 2.8 A. We have studied the effects of amino acids and of water using A density functional based [...]

Modeling of the Deformation of Living Cells Induced by Atomic Force Microscopy

Rudd R.E., McElfresh M., Baesu E., Balhorn R., Alleny M., Belak J., Lawrence Livermore National Lab., US

We describe finite element modeling of the deformation of living cells by atomic force microscopy (AFM). Cells are soft systems, susceptible to large deformations in the course of an AFM measurement. Often the local properties, [...]

Molecular, Surface and Continuum Issues in the Capture of Bacteria Particles by Solid Aerosols

Kohlberg I., Boezer G., Greer W., Good R., Institute for Defense Analyses, US

In this study, we develop the design parameters required to remove airborne biological particles by impact with scavenging aerosols. The conditions for capturing air-borne biological particles for a head-on collision are deter-mined as a function [...]

Sector: Medical & Biotech