Medical & Biotech – Page 185 – TechConnect Briefs

The Microchips for Alzheimer Disease Diagnosis

Napieralska M., Zubert M., Napieralski A., Liberski P.P., Technical University of Lodz, PL

The Alzheimer disease is belongs to a group of neurodegenerative diseases characterised by an accumulation of extraneuronal filamentous material consisting of _-sheet proteins of various biochemical properties. Clinically, these diseases manifest as dementia is permanent [...]

Multi- and Single- Atoms Liquid Flow Systems for Nano-sized channels

Lu M-C, Tseng F-G, Hsieh H-M, Chieng C-C, National Tsing Hua University, TW

Flow based assays use continuous forward flow in micro/nano-fluidic systems to deliver and transport biomedical sample to destined spots for biomedical diagnosis. Accurate dose control, less drag force from contact surface, and simpler flow system [...]

Visualization of Fluidic and Reaction Dynamics in Microchannels

Kawazumi H., Muraki A., Kanno K., Maeda H., Kinki University, Kyushu, JP

An easy-to-use and low cost microreactor made of polymethylmethacrylate was mechanically fabricated with a microchannel. The laminar flow behavior was investigated by visualizing the flow of red and green aqueous solutions. Digitized color images from [...]

Electrode Shapes for Electrowetting Arrays

Lienemann J., Greiner A., Korvink J.G., Albert Ludwig University, DE

We calculate the potential energy of an electrowetting array for different shapes and sizes of interdigital edge structures. To understand the dynamic effects at the beginning of the droplet motion is crucial for the optimization [...]

Low Energy Conformations of a Three-Helix Peptide in a All-Atom Biomolecular Forcefield

Herges Th., Schug A., Wenzel W., Forschungszentrum Karlsruhe, DE

Protein structure prediction remains one of the main outstanding challenges of theoretical biophysical chemistry. Its goal is to predict the fully three-dimensional tertiary structure of the protein on the basis of its amino acid sequence [...]

Highly Integrated Transparent Microchannel Chips for Continuous-flow PCR

Sun K., Matsuo S., Misawa H., Satellite Venture Business Laboratory, The University of Tokushima, JP

A microchannel chip for continuous-flow polymerase chain reaction (PCR) was developed using transparent materials. The microchannel was fabricated on a quartz glass substrate using standard photolithography and wet-etching techniques, and was sealed by another quartz [...]

Lab-on-Chip

A Homogenous Small Molecule Microarray for Enzymatic Assays

Ma H., Wang Y., Pomaybo A.S., Tsai C., Schmidt S.P., Morewood Molecular Sciences, Inc., US

Small molecule microarray as an emerging technology promises to play a pivotal role in chemical genetics. However, in spite of the fast development of this technology special requirements, such as the immobilization of small molecules [...]

Assembly of Oriented Virus Arrays by Chemo-Selective Ligation Methods and Nanolithography Techniques

Camarero J.A., Cheung C-L, Lin T., Johnson J.E., Weeks B.L., Noy A., De Yoreo J.J., Lawrence Livermore National Laboratory, US

Many experimental techniques in biology and biophysics, and applications in diagnosis and drug discovery, require proteins immobilized on solid substrates. In fact, the concept of arrays of proteins attached to a solid support has attracted [...]

Immunosensing Using Fabricated protein Microarrays

Howell S.W., Inerowicz H.D., Guirl L., Regnier F., Reifenberger R., Purdue University, US

Patterned microarrays of antibodies to specific bacteria were used to perform a series of bacterial immunoassays of E. Coli 0157:H7 and Renibacterium Salmoninarum (RS). Microarrays were fabricated using microcontact printing (MCP) and characterized using scanning [...]