Medical & Biotech – Page 163 – TechConnect Briefs

Regular Nano-Pores Fabricated By UV Cross-Linking Non-softbaked SU-8 Resist In a Solvent Evaporation Controlled Environment

Chang C-J, Tseng F-G, Yang C-S, National Tsing Hua University, TW

This paper proposes a novel technology to fabricate 3D nano pore structures in SU-8 resist, a widely employed resist in MEMS and Bio-chips. Controlling the evaporation rate in SU-8 fabrication process, regular porous structures with [...]

Development of Nano-sized Protein Arrays using Block Copolymer Self-Assemblies

Jung H-T, Jung J-M, Kwon K.Y., Ha T-H, Chung B.H., Jung H-T, Jung J-M, Korea Advanced Institute of Science and Technology, KR

The single molecule approach is potentially of great technological interest as a complementary means to obtain information about protein conformation or molecular interaction. The measurement for molecular interaction in single molecule level requires that the [...]

Nanotechnology Based on Spatially Fixed ds DNA (RNA) Molecules

Zakharov M.A., Yevdokimov Yu.M., Skuridin S.G., Nechipurenko Yu.D., Engelhardt Institute of Molecular Biology of RAS, RU

A new strategy of creating nucleic acid nanostructures is described. Our approach is based not on isotropic dsDNA (or RNA) molecules, but on these molecules fixed in spatial structure of their liquid-crystalline particles.The nanostructure formed [...]

Ca-Mg Phosphate Nano-Crystals for High Efficiency Gene Delivery and Expression in Mammalian Cells

Chowdhury E.H., Akaike T., Tokyo Institute of Technology, JP

Significant efforts are now being made for the development of non-viral gene-delivery techniques as alternatives to the viral vectors for basic research and clinical medicine. Despite existence of a wide variety of non-viral techniques particularly [...]

Amelogenin Nanospheres Supra-Molecular Assembly and the Preferential Orientation of Apatite Crystals

Moradian-Oldak J., Du C., Falini G., University of Southern California, US

Amelogenin self-assembly into nanospheres has been recognized as a key factor in controlling the oriented and elongated growth of carbonated apatite crystals during tooth enamel formation. We investigated the process of amelogenin self-assembly into higher [...]

Colloidal ß-TCP Facilitates Synthesis of Collagen Nano-composite

Shibata Y., Yamamoto H., Miyazaki T., Showa University, JP

Recently, hydroxyapatite/collagen composites have received much attention in the field of tissue reconstruction, because human bone is mainly composed of hydroxyapatite and collagen fibers. However, these composites cannot be synthesized without secondary treatments, therefore the [...]

Toxicity of Nanomaterials to Living Cells

Jin Y., Wu M., Zhao X., University of North Dakota, US

We have investigated the toxicity of nanomaterials to living cells at the cellular and molecular levels. Recently, nanomaterials have being rapidly developed and shown great potential for use in various bioapplications due to their unique [...]

Calcium-Alginate Nanoparticles for Nonviral Gene Delivery

You J-O, Peng C-A, University of Southern California, US

Natural biopolymers are widely used in the filed of drug and gene delivery. In this study, alginate nanoparticles were prepared using water-in-oil microemulsion as a template followed by calcium crosslinking of guluronic acid units of [...]

Bioactive Ferrimagnetic Glass-Ceramics for Magnetic Induction Hyperthermia

Bretcanu O., Vernè E., University "Politecnico di Torino", IT

Ferrimagnetic glass-ceramics are potential candidates for magnetic induction hyperthermia, which is one form of inducing deep-regional hyperthermia, by using a magnetic field. The aim of this work is the preparation and characterization of innovative bioactive [...]

Nanofabrication of Bioselective Materials using Diverse Nanolandscapes Displayed on Live Viruses

Petrenko V.A., Olsen E.V., Sykora J.C., Kouzmitcheva G.A., Sorokulova I.B., Brigati J.R., Chen I-H., Chin B.A., Vodyanoy V.J., Auburn University, US

Filamentous phage, such as fd used in this study, are thread-shaped bacterial viruses. Their outer coat is a tube formed by thousands equal copies of the major coat protein pVIII (Figure 1, left). We constructed [...]