Medical & Biotech – Page 146 – TechConnect Briefs

Dendrimer Nanoparticles for Extending Biosensor Lifetime

Qian X., Tabacco M.B., Smiths Detection, US

Smiths Detection has been developing semi-selective optical biosensors for the direct airborne detection of the four primary classes of biological warfare agent: bacteria, bacterial spores, toxins and viruses. The sensors have good sensitivity and selectivity. [...]

Bio Sensors and Diagnostics

Increasing the Thermal Stability of Self-Assembling DNA Nanostructures by Incorporation of isoG/isoC Base Pairs

Ho K., Li H., Roesch E.B., Sherrill C.B., Prudent J.R., LaBean T.H., Duke University, US

Self-assembling DNA nanostructures are currently being developed for a variety of applications in nanofabrication and molecular computing. For many uses, these nanostructures would benefit from increased thermal stability. However, increasing the lengths of sticky-ends that [...]

Patterned nanofiber meshes for biomedical applications

Neves N.M., Campos R., Pedro A., Cunha J., Macedo F., Reis R.L., University of Minho, PT

The typical end-product of the electrospinning process is a randomly aligned fibre mesh or membrane. This is a result of the electric field generated between the drop of polymer solution at the needle and the [...]

In vitro testing of the penetration and permeation of nanomaterials on a artificial human skin model

Weimer M., Mertsching H., Brunner H., Fraunhofer Institute of Interfacial Engineering and Biotechnology, DE

We established a tissue engineered 3D human skin model. This interactive 3D-co-cultre consists of living human primary keratinocytes with a well-differentiated stratum corneum and an epidermal layer. The dermal layer is composed of a Type [...]

Improvement of Polycaprolactone Nanofibers Topographies: Testing the Influence in Osteoblastic Proliferation

Martins A., Cunha J., Macedo F., Reis R.L., Neves N.M., University of Minho, PT

The nanofiber technology of present interest focuses on the electrospinning technique, which conveniently allows the preparation of fibrous materials with very fine diameters ranging from submicron to several nanometers. With the ability to form nanofibrous [...]

DNA/Cellulose hybrid nanomaterials

Mangalam A., Simonsen J., Benight A.S., Oregon State University, US

One potential advantage of nanotechnology is the ability to engineer bottom-up hierarchical assembly of nanoparticles into functional macroscale materials and devices. The most promising mechanism for accomplishing this is self-assembly. In this project, an advanced [...]

3D Microfabricated Bioreactors

Xia C.-G., Fang N., University of Illinois at Urbana-Champaign, US

We present here an innovative three dimensional microfabrication technology that will serve as a vehicle to enable vascularized bioreactors for in vitro tissue culture. The core of our microfabrication technology is a high-resolution projection micro [...]

Transport of Multiple Enzymes through Semipermeable Membrane and Effect of Surfactants

Trigo C., Leung S.W., Bhushan A., Daniels C.K., Lai J.C.K., Idaho State University, College of Engineering, US

Surfactants are known to influence functions of many proteins in membranes, cells and tissues. Because most studies to elucidate the effects of surfactants on membrane-bound proteins and cells employed heterogeneous or complex systems, it is [...]

Nano-Structured Biodegradable Ceramics for the Treatment of Osteoporosis

Balasundaram G., Webster T.J., Purdue University, US

There are a number of applications requiring bone-building agents. For example, osteoporosis is a disease resulting in weak bone. However, no current effective prevention and treatment methods exist for osteoporosis. For these reasons, in this [...]