Medical & Biotech – Page 12 – TechConnect Briefs

Modular Nanoparticle Probes for Personalized in Vitro and in Vivo Imaging of Cancer Cell Populations

Nallathamby P.D., Cowden-Dahl K., Roeder R.K., University of Notre Dame, US

The high mortality and poor prognosis for women diagnosed with ovarian cancer is mainly due to late diagnosis. Improved detection of primary tumors and recurrence after chemotherapy is, therefore, crucial to reduce ovarian cancer mortality [...]

Cancer Nanotechnology

Novel fluorescent nanoparticles for ultrasensitive identification of nucleic acids by optical methods

Westergaard Mulberg M., Taskova M., Okholm A., Kjems J., Astakhova K., University of Southern Denmark, DK

There have been an enormous interest in new amplification-free detection methods. A tremendous progress has been made in fluorescence based optical detection of biomolecules, which here resulted in the synthesis of novel ultra bright fluorescent [...]

Carcinoma cellular uptake, imaging, and targeting by RGDS- and TAT-conjugated upconversion and/or magnetic nanoparticles

Horák D., Kostiv U., Proks V., Jirák D., Institute of Macromolecular Chemistry AS CR, CZ

Specific targeting and in vivo visualization of cancer cells is of crucial importance for early detection and treatment of cancer. We have developed monodisperse poly(ethylene glycol) (PEG)-modified SiO2-coated Fe3O4 superparamagnetic nanoparticles [1] with size tuned [...]

Point-of-Care (POC) Micro Biochip for Cancer Diagnostics

Nunna B.B., Lee E-S, New Jersey Institute of Technology, US

American cancer society stated that a total of 1,685,210 new cancer diagnosed cases out of which 595,690 deaths from cancer are expected to be reported in the United States of America in 2016. Unfortunately Cancer [...]

Amplification-free liquid biopsy by fluorescence approach

Uhd J., Taskova M., Okholm A., Astakhova K., University of Southern Denmark, DK

Diagnostics of cancer associated ctDNA, BRAF V600E, KRAS G12D and KRAS G13D respectively. By the use of modern fluorescence microscopy and fluorescently labeled mutation specific LNA/DNA probes. Which resulted in a mutation specific detection.

Diagnostics & Bioimaging

Positively charged Ag-dendron conjugates: Stability enhanced AgNPs for biomedical applications

Cho T.J., Liu J., Hackley V.A., National Institute of Standards and Technology, US

We developed positively charged silver nanoparticles ([Ag-Ds]+), nominally 20 nm in diameter, using dendron chemistry combined with reduction of silver nitrate in the presence of sodium borohydride. The conjugate was developed within the context of [...]

Application of a Next Generation Hand Held Antimicrobial Cold Plasma Technology

Kim H., Izadjoo M., Izadjoo S., Marcel V., Truong H., Izadjoo M., Izadjoo S., Trideum Biociences and ChiScan LLC, US

Due to emergence of antibiotic and multi-drug resistant infectious agents, there is a growing need for development of novel and effective antimicrobial therapeutics and devices. Innovative anti-infective treatment modalities, particularly for multi-drug resistant infections and [...]

miRNA Expression Analysis in HEp-2 Cells after Gold Nanorod Application

Montgomery A., Bawage S., Chaudhary A., Singh S.R., Vig K., Alabama State University, US

Gold Nanoparticles are popular because of their use in drug delivery and other biomedical applications. However, not much is known about their toxicity. The purpose of the present study was to evaluate the toxicity of [...]