The application of 3D printing to study microfluidic architecture for ‘on chip’ mixing systems for SRCD and UV spectroscopy

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Circular dichroism (CD) is the differential absorption of left- and right-handed circularly polarized light. It is a form of spectroscopy used to determine the optical isomerism and secondary structure of molecules, and to study a wide variety of chiral materials in solution, particularly biologically important molecules such as proteins, nucleic acids, carbohydrates, lipids and drugs. The benefit of carrying out such experiments using synchrotron radiation is that the light available is several orders of magnitude higher in intensity than that available using conventional CD instruments, thereby providing a much higher signal-to-noise ratio over a wide wavelength range (140-700 nm). This paper will detail the development of a technique for rapidly producing 3D printed microfluidic channels in transparent polymer flow cells that enables the rapid and low-cost evaluation and iteration of microfluidic channel geometries. Permitting the flow through novel microfluidic devices to be interrogated thoroughly and the design optimized prior to making the significant financial and most crucially time commitment to the UV compatible flow cell for presentation to the synchrotron.

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Journal: TechConnect Briefs
Volume: 4, Advanced Manufacturing, Electronics and Microsystems: TechConnect Briefs 2015
Published: June 14, 2015
Pages: 331 - 334
Industry sector: Sensors, MEMS, Electronics
Topic: Micro & Bio Fluidics, Lab-on-Chip
ISBN: 978-1-4987-4730-1