Schianti J.N., Cerize N.N.P., Oliveira A.M., Derenzo S., Gongora-Rubio M.R.
Polytechnic School - University of São Paulo, BR
Keywords: microfluidic, nanoparticles, nanoprecipitation, Rifampicin
In this work the results of a study of Rifampicin nanoprecipitation through antisolvent technique are presented, using microfluidic devices. Rifampicin is commonly used in Tuberculosis treatment and presents variability in bioavailability. The particle size and morphology were evaluated by observing the influence of fluid flow rates, the relation between flow rates, the presence of surfactants and Rifampicin concentrations. The size and morphology contribute to accelerate the dissolution rates, increasing biovailability.
Journal: TechConnect Briefs
Volume: 1, Nanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites
Published: June 13, 2011
Pages: 229 - 232
Industry sector: Advanced Materials & Manufacturing
Topic: Nanoparticle Synthesis & Applications
ISBN: 978-1-4398-7142-3