Papers – Page 716 – TechConnect Briefs

Targeted Aptamer-Nanoparticles to Diminish Drug Resistance of Cancer Cells in vitro Study

Basto P., Alexis F., Levy-Nissenbaum E., Langer R., Farokzhad O., Massachusetts Institute of Technology, US

Using prostate cancer as a model, we report the drug release of pacitaxel and doxorubicin from aptamer-poly (D,L lactic co glycolic acid)-poly(ethylene glycol) (PLGA-PEG) nanoparticles used to target prostate-specific membrane antigen (PSMA), a well characterized [...]

Polymer Nanospheres for Improved Drug Delivery of Protein Therapeutics and Viral Antigens

Castor T.P., Aphios Corporation, US

Biologically adherent polymeric microsphere carriers have been shown to be effective in the oral delivery of proteins such as insulin and DNA plasmids. These microspheres are comprised of hydrophobic copolymers that appear to have a [...]

A Targeted Nanotechnology-based Therapeutic System for the Combined Chemoprevention of Colon Cancer

Prabhu S., Kanthamneni N., College of Pharmacy, Western University of Health Sciences, US

Colorectal cancer (CRC) is the second most common cause of cancer death in the USA. Current research is shifting the focus from chemotherapy to chemoprevention. The overall goal was to develop a low dose, novel [...]

Targeted Nanoparticle-Polypeptide Conjugates for Breast Cancer Treatment

Alexis F., Basto P., Radovic-Moreno A., Langer R., Farokhzad O.C., Brigham and Women's Hospital, Harvard Medical School, US

We have developed a polymeric targeted nanoparticle-polypeptide conjugates that shows cell binding speficity and stealth properties. The targeted naoparticles binds and are taken up efficiently by Her2 expressing breast cancer cells. These nanoparticles represent a [...]

Delivery of Shiga Toxin 1 A Subunit into Epithelial Cells Using Silica-Based Nanowires

Kwon N.H., Beaux M., Sheng H., Ebert C., Wang L., McIlroy D.N., Hovde C.J., Bohach G.A., University of Idaho, US

Silica-based nanowires were used to introduce the Shiga toxin 1 A subunit (StxA1) into bovine and human epithelial cells. We extended our previous technology which employs fibronectin (Fn) as a ligand to induce integrin-mediated uptake [...]

Differential Uptake of PEG-Silica-FITC Nanoparticles by Human Breast Cancer Cells and Normal Human Breast Epithelial Cells

Iwakuma N., Sharma P., Delano M.J., Moldawer L.L., Moudgil B.M., Grobmyer S.R., University of Florida, US

Background: An understanding of uptake of nanoparticles (NPs) by human cancer cells and non-cancer cells is important for the development of NPs as novel cancer therapeutic and diagnostic agents. Hypothesis: Uptake of NPs is increased [...]

Archives: Papers

Targeted Aptamer-Nanoparticles to Diminish Drug Resistance of Cancer Cells in vitro Study

Polymer Nanospheres for Improved Drug Delivery of Protein Therapeutics and Viral Antigens

A Targeted Nanotechnology-based Therapeutic System for the Combined Chemoprevention of Colon Cancer

Targeted Nanoparticle-Polypeptide Conjugates for Breast Cancer Treatment

Delivery of Shiga Toxin 1 A Subunit into Epithelial Cells Using Silica-Based Nanowires

Differential Uptake of PEG-Silica-FITC Nanoparticles by Human Breast Cancer Cells and Normal Human Breast Epithelial Cells

An Investigation of Cellular Toxicity of Carbon Nanomaterials in African American Breast Cancer Cells

Nanoprobe for Optical Molecular Imaging

Chemical imaging using molecular spectroscopy – providing answers to fundamental biomedical questions at the nanoscale

Optimisation of magnetoliposomes for biomedical multi-tasking; potential dual contrast agents and drug delivery vehicles