Papers – Page 626 – TechConnect Briefs

2-Nitroimidazole as Potential Nanoprobe in Hypoxia Imaging by MRI/PET

Sharma A., Sharma R., Sharma A., Sharma R., University of North Carolina, US

2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19F- and 31P MR methods. Despite the success of mesonidazole and SR-4554 compounds, very little is known of its hepato-cytotoxicity if it can be potential [...]

Multiplexed Proteolytic Enzyme Assay Based on Energy Transfer between Quantum Dots and Gold Nanoparticles

Oh Y.H., Kim H-S, Kim Y.P., Kim H-S, Kim Y.P., Korea Abvanced Institute of science and Technology, KR

Proteases are key enzymes that regulate both normal and malignant tumor progress. Evaluating these enzymes and their inhibitors, therefore, has a great potential to diagnostics or therapeutic treatment against specific diseases or disorders. We have [...]

Towards nanosized particles in pharmaceutical industry

Bieri N.R., Meier U., Goncalves E., Zimmermann D., Juhnke M., Thakur R., Novartis Pharma AG, CH

The pharmaceutical industry is facing the problem of an increasing number of drug substances in development which are either poorly water soluble or show pH dependency of solubility. Drug targeting and tailored delivery poses additional [...]

Nanomaterial: A realistic business case for Pharma

Keller T.H., GlaxoSmithKline, UK

Main points from a pharma perspective: Review nanotech’s current position Nanotech and its realistic potential Nanotech and the barriers into the clinic GSK’s position on the subject matter

Effect of Medical Device Substrate Material on Nanoparticulate Silver Efficacy

Dair B.J., Kennedy K.M., Casas R.S., FDA, US

Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nano-scale regime increases [...]

Regulation of Nanotechnology in the Environment

Lehrenbaum W.U., Zarghamee R., Leopold Jr. C., Pillsbury Winthrop Shaw Pittman LLP, US

In this paper we examine the current state and likely future path of nanotechnology regulation by the U.S. Environmental Protection Agency (“EPA” or “the Agency”). We also explore a number of initiatives that have arisen [...]

From Biotechnology to Nanotechnology: Parallels in State Regulatory Review

Bosso C.J., McCarty K., Northeastern University, US

This case study of the process by which Massachusetts reviewed and revised environmental regulations pertaining to the biotechnology industry provides useful insights into the potential regulatory issues facing the nanotechnology sector and lessons about how [...]

Nanosize Iron Oxide for CO Oxidation

Wu Z., Fransson M., Zhou B., Headwaters Technology Innovations LLC, US

Transition metal oxides are desirable alternatives to precious metals based catalysts for CO oxidation since they are less costly. Several nanosize iron oxides were prepared by using Headwaters Technology Innovation (HTI) NxCat® colloidal chemistry nanotechnology. [...]

A Non-Contact Culture Model for Investigating Cell Signaling and Nanotoxicity

Gao W.J., Dukhande V.V., Jandhyam S., Wang Y.-H., Gu H.-Y., Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Leung S.W., Idaho State University, US

There is general agreement that in vitro cell model systems offer many advantages over in vivo model systems in elucidation of cell signaling and other mechanisms underlying a toxicant’s effect. While the 3-D cell models [...]

Impact of CNT Ingestion on in Vitro Cells

Mangir T., Chaves J., Chaves S., Chaves J., Chaves S., CSULB, US

In this paper we will describe our results of CNT ingestion in in vitro cell cultures. We will present AFM pictures of the observed impact of CNT on cell growth. We will describe the bio-nano [...]