Papers – Page 550 – TechConnect Briefs

Modeling of Polymer-Drug Interactions in Biodegradable Tyrosine-Based Nanospheres Using Molecular Dynamics Simulations and Docking

Costache A.D., Sheihet L., Knight D.D., Kohn J., Rutgers University, US

The intensive labor and high cost of developing new vehicles for the delivery of drugs in a controlled manner, highlights the need for a change in their discovery process. Predictive computational models can be used [...]

Diskettes of mucoadhesive polymeric nanoparticles for oral (buccal) transmucosal delivery of Fluoxetine hydrochloride: formulation and characterization

Sapre A., Parikh R., Gohel M., L.M. College Of Pharmacy, IN

Nanoparticles based mucoadhesive system (diskettes), an alternative novel transmucosal (buccal) delivery of Fluoxetine hydrochloride (antidepressant drug, highly first pass effect) was developed. In this study, the drug was encapsulated into Sodium / Calcium salts of [...]

Formulation and Development of Novel Insitu Nasal Gel Containing Glibenclamide Nanoparticles

Gohel M.C., Par R.K., Patel K.D., L.M. College Of Pharmacy, IN

To provide an alternative route (non-swallowing) and compliance to patient (controlled release), nasal delivery of sulfonylureas is one of the best option among other routes for type II diabetes. Glibenclamide was selected as a model [...]

Synthesis and Biopharmaceutical Characterisation of a New Poly hydroxyethyl

Qi X-H, Lin W., He Q., Guan X-H, Nanjing Medical University, CN

A promising approach to improve drug delivery is to modify a polymeric backbone structure by means of copolymerization. Such obtained macromolecular prodrugs (polymer–drug conjugates) may offer many advantages compared to other drug delivery systems: increased [...]

Imprint Lithography-Based, Multimodal Contrast Agents and the Effect of Shape and Size on Biodistribution

Herlihy K.P., Merkel T.J., DeSimone J.M., UNC Chapel Hill, US

Polymer research and modern medicine are at a critical juncture. Many state of the art, small molecule therapeutics are difficult to deliver effectively because of poor solubility and rapid elimination by the reticuloendothelial system. In [...]

In Vivo Toxicity Study of Gold Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Nair B., Kasturirangan V., Kariapper M.S.T., Nigavekar S.S., Toth K., Rustum Y.M., El-Jawahri A., Bizimungu R., Lesniak W., Balogh L.P., Roswell Park, US

We previously reported on the in vitro toxicity assessment of differently charged dendrimer-gold nanocomposites on normal cells (human endothelial cells) and prostate cancer cells (Khan et al., 2008). In this study we evaluate the in [...]

Use of PBMC Partitioning to Predict RES-Uptake of a Nanoemulsion in a Colon Cancer Xenograft

Devalapally H., Clogston J.D., Amiji M.M., McNeil S., Stern S.T., SAIC-Frederick, National Cancer Institute at Frederick, US

Nanotechnology platforms have emerged as versatile carrier systems for delivery of active molecules to tumors. Nanoparticle-based formulations have demonstrated enhanced efficacy and decreased toxicity in comparison to conventional drugs. These carrier systems often encounter rapid [...]

Carbon Nanotubes as Molecular Nanocarriers for Antibody Delivery and Photothermal Ablation of Breast Cancer Cells

Panchapakesan B., Wickstrom E., University of Louisville, US

In this paper, the utilization of carbon nanotubes as nanocarriers for antibody delivery to IGF1R and HER2 surface receptors and selective thermal ablation of breast cancer cells is presented. IGF1R and Her2 surface receptors are [...]

Method of LANTCET for cancer diagnostics and treatment at cell level

Hleb E.Y., Zastinskaya I.A., Ilyukova I.I., Semenenya I.N., Hafner J.H., Hanna E.Y., Myers J.N., Zhdanok S.A., Lapotko D.O., A. V. Lykov Heat & Mass Transfer Institute, BY

We have developed the method of LANTCET (laser-activated nano-thermolysis as a cell elimination technology) for selective detection and destruction of individual tumor cells by generating intracellular photothermal bubbles around the clusters of gold nanoparticles. Bare [...]

PMMA/SWCNTs Composites for Prostate Brachytherapy MRI Contrast Agent Markers

Martirosyan K.S., Stafford R.J., Elliott A.M., Frank S.J., University of Houston, US

Prostate brachytherapy (PB) is an alternative to traditional external beam radiation or surgery for men who have prostate cancer. PB used implanted radioactive titanium seeds and has increased in popularity over recent years due to [...]