Papers – Page 35 – TechConnect Briefs

Numerical investigation of Electric field, Ion Transport and pH damage during Electrochemical Treatment of Tumors: Effects of physicochemical reactions and chlorine bleaching

Mokthare A., Reddy S.K., Furlani E.P., University at Buffalo, US

Electrochemical therapy (EChT) is a promising alternative to conventional tumor treatment due to its relatively high efficiency, flexibility, reduced side effects and versatility. Tumor electrolysis, a form of EChT, utilizes low-level direct electric current (DEC). [...]

Overcoming Challenges in Manufacturing Scale-Up of Plasmonic Gold Nanorods: Bringing Photothermal Therapy to the Clinic.

Pagliaro L., Siva Therapeutics Inc, US

Siva Therapeutics is developing a simple, safe, and effective adjunct cancer treatment termed Targeted Hyperthermia™, which generates therapeutic heat emanating from within solid tumors using systemically injected precision gold nanorods and an infrared light engine [...]

Graphenoid plates in glioma therapy.

Grodzik M., Szczepaniak J., Strojny B., Jaworski J., Wierzbicki M., Jagiello J., Soltan E., Mandat T., Warsaw University of Life Sciences (WULS), PL

Glioblastoma multiforme (GBM) is a malignant primary tumour. The presence of necrotic areas and atypical vascularisation as well as the presence of atypical cells with nuclear pleomorphism and high proliferative ratio constitute the most important [...]

Customized Nanoparticle Probes for Biomedical Imaging, Diagnostics and Therapeutics Applications

Nallathamby P., University of Notre Dame, US

The modular synthetic approach that was developed to design a spectral library of core-shell nanoparticle contrast agents, which will have broad applications in biomedical imaging due to the potential for multi-modal imaging (e.g., fluorescence, MRI, [...]

RECAL: A New Ultrastable Luminescent Probe for Bioimaging

Borders B.C., Kang C.H., Brozik J.A., Photon Biosciences, LLC, US

Luminescent probes, such as fluorescent proteins, fluorescent dyes, phosphorescent dyes, and quantum dots, are important tools in biology, biophysics, and medical diagnostics. While these tools are incredibly useful and are suitable for use in many [...]

Functionalized Carbon Nanotube-based Microelectronic Sensor Array for Early Diagnosis of Alzheimer’s Disease

Johnston A.S., Tang Y., Alam M.M., InnoSense LLC, US

We designed and developed a lab-on-a-chip for the early diagnosis of Alzheimer’s Disease (AD) based on our patent-pending innovative nanotechnology by utilizing patterned microelectronic sensor devices for detecting Food and Drug Administration (FDA)-approved AD biomarkers [...]

Quantitative Electrolateral Flow Immunosensor (ELLI): Dengue Triage and Stroke Prognosis Case Studies

Sinawang P.D., Fajs L., Marks R.S., Ben-Gurion University of the Negev, IL

The development of a rapid, affordable, and sensitive diagnostic kit for point-of-care is important in most healthcare settings; however, only a few exhibit the needed quantitative capability. Our technology, ELLI, is a patented diagnostic device [...]

Nanobiomimetic Superlattice Superconductive/Memristive Organometallic Devices at Room Temperature Serve as Chronoamperometric Sensors for sub fg/mL Collagen-1 Detection in Human Serum

Chen E.T., Thornton J.T., Kissinger P.T., Duh S-H, Advanced Biomimetic Sensors, Inc., US

Superconductive/Memristive devices have potential applications in supercomputing and in health industry was proposed in literature. Clinically detection range at low concentration for collagen-1 is difficult to accomplish due to the denaturing of protein Matrix Matelloprotinase-2 [...]

Multiplex Express In Vitro Diagnostics based on Magnetic Nanoparticles

Nikitin M.P., Nikitin P.I., Guteneva N.V., Bragina V.A., Znoyko S.L., Orlov A.V., Gorshkov B.G., Nikitin M.P., Nikitin P.I., General Physics Institute, Russian Academy of Sciences, RU

Magnetic nanoparticles (MP) have provided many breakthrough solutions for life science. The immense potential of MP as labels in advanced immunoassays stems from the fact that they, unlike optical labels, can be easily detected inside [...]

Hybrid Programmable Peptide Crosslinkers as Enzyme-Regulated Drug Delivery Vehicles

Rouge J.L., University of Connecticut, US

Biology has evolved the quintessential nucleic acid delivery vehicle, the virus, using proteins built from self-assembled peptide subunits. These viral protein coats are then degraded by specific enzymes, depending on their location, releasing their contents [...]