Nanoparticles Prepared by Self-assembly of Chitosan and Poly-gamma-glutamic Acid

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The technique of self-assembly of polyelectrolytes opens many new opportunities to achieve idea models as delivery system. The oppositely charged biopolymers can self-assemble by the attractive interaction between the functional groups. The electrostatic interactions between charged macromolecules can result stable self-assembled nanosystems, films or hydrogels. A variety of studies have focused on preparation and characterization of these polyelectrolyte complexes. The present investigation reports the formation of polyelectrolyte complexes of poly-gamma-glutamic acid (PGA) and chitosan (Chit) by self-assemble in aqueous media at room temperature. Self-assembly of these polyelectrolytes was evolved by ion-ion interaction between the carboxylic groups of linear PGA chains and the amino groups of Chit linear chains formed stable nanoparticles. Complexation was observed and separated spherical particles or aggregates were obtained.

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Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 143 - 146
Industry sectors: Advanced Materials & Manufacturing | Personal & Home Care, Food & Agriculture
Topicss: Advanced Materials for Engineering Applications, Personal & Home Care, Food & Agriculture
ISBN: 1-4200-6183-6