Multiscale Design of a Laser Actuated Micro Bubble Array Acoustic-Fluidic Microdevice for Bioanalytical and Drug Delivery Applications


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Next generation fluidic micro-nano devices will require precise control of force fields within a device and their interaction with a biological sample. Current force field designs use mechanical structures such as cantilevers, optical fields e.g. laser tweezers, or electrokinetic fields for example dielectrophoretic devices. All of them suffer from design complexity, small forces, long actuation times, and others. We propose a novel opto acoustic device for fast generation of 3D spatially distributed large force fields within the micro/nano fluidic device. The basic concept is to dynamically produce field of oscillating nano bubbles which will generate desired 3D pressure and/or flow fields within the device. This concept can be used for bioanalytical applications in vitro exploration of novel drug formulations, novel drug delivery modalities, e.g. to cells and tissues, and for micro/nano surgical applications. Our overall concept as well as the device has been designed based on multiscale simulation of bubble dynamics, laser beam physics, fluid flow, cavitation, and acoustics. The major innovation of our work is to explore space/time controlled bubble array for the generation of desired force fields. This paper will present two essential modeling steps: 1) a novel analytical analysis on the relation between initial gas bubble radius and laser pulse energy and 2) 3D simulation results of mirofluidic device with array of nano-bubbles generating desired spatial/temporal force fields.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2008: Microsystems, Photonics, Sensors, Fluidics, Modeling, and Simulation – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 3
Published: June 1, 2008
Pages: 421 - 424
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topic: Micro & Bio Fluidics, Lab-on-Chip
ISBN: 978-1-4200-8505-1