Methods for the Prediction of Nanoparticle Fate, Transport and Receptor Exposure in an Aqueous Environment

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The development and applications of nanomaterials have presented a unique problem to environmental scientists and risk assessors. Until now, the models and paradigms used to predict the behavior of chemicals in the environment and thereby the potential for exposure and effect have been firmly rooted in the principals of solution chemistry such as molarity, partition, fugacity, etc. However, to evaluate and predict the behavior of nanomaterials in the environment, new considerations that take into account conditions of surface chemistry need to be added to the standard model. These include environmental and material properties such as buoyancy, surface area, viscosity, charge accumulation, steric factors, and Hakman forces. Recently, we presented a method for predicting the mass transport and stability of nanomaterials in the environment using competitive probability kinetics. Furthering on this research, this work looks at predictive methods of determining the probability of reaction (P) given projected rates of interaction. This is placed in the context of likely modes of receptor exposure. With consideration of bioavailability and toxicological potency and efficacy, this will permit the direct risk evaluation of potential environmental impacts within the paradigm currently in use.

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Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 608 - 611
Industry sectors: Medical & Biotech | Personal & Home Care, Food & Agriculture
Topics: Environmental Health & Safety of Nanomaterials
ISBN: 1-4200-6183-6