Influence of water-soluble polymers and surfactants, on mebendazole solubilization by _- and permethyl-_-cyclodextrins

Ba O-M., Lahiani-Skiba M., Joudieh S., Bounoure F., Lahiani-Skiba M., Skiba M.
Université de Rouen, FR

Keywords: Cyclodextrins, surfactants, water-soluble polymers

The objective of this work was to determine the influence of pH, water-soluble polymers and surfactants on mebendazole solubilization by beta- and permethyl-beta-cyclodextrins (beta-CD and PM-beta-CD). Mebendazole is an antihelmintic active drug used against a variety of intestinal parasites and potentially active against extra-intestinal parasitic infections. However, its low solubility renders it difficult to use. Cyclodextrins (CD) are able to increase the apparent solubility of poorly water-soluble active drugs by forming complexes

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Pages: 386 - 389
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-1-4200-8504-4