Thote A.J., Gupta R.B.
Auburn University, US
Keywords: controlled drug release, dexamethasone phosphate, PLGA, s/o/o/o, SAS-EM, sustained
The problem of initial burst release, in sustained drug delivery devices was resolved by reducing the active pharmaceutical ingredient particle size by using Supercritical Antisolvent technique with Enhanced Mass-transfer (SAS-EM)., Encapsulation was performed using a nonaqueous s/o/o/o technique giving high encapsulation efficiencies for hydrophilic drugs. Using SAS-EM, dexamethasone phosphate nanoparticles were obtained in the range of 150-200 nano-meter. Upon encapsulation in PLGA, composite microspheres of ~70 micro-meter were obtained with about 90% drug encapsulated. The in-vitro drug release study of these microparticle/nanoparticle composites showed sustained drug release over 700 hours with negligible burst release.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Pages: 116 - 119
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 0-9767985-0-6