Effects of Silicon Nanowires on HepG2 Cell Adhesion and Spreading

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The unique capabilities of nanomaterials make them good candidates for catalysts, biosensors, and even drug carriers. However, interactions of nanomaterials with biological systems and the environment may lead to potential toxicity. While there have been reports on the cytotoxicity of carbon nanotubes, quantum dots, gold nanoparticles, and the biocompatibilities of carbon nanotubes, no study has yet appeared on the biological effects of silicon nanowires, which are becoming increasingly important as a nanomaterial. Silicon nanowires (SiNWs), as a one-dimensional nanomaterial, typically are composed of a single crystalline silicon core and an amorphous SiOx sheath. Their outstanding properties such as quantum size effects, diameter-dependent thermal conductivity and large piezoresistance coefficient have attracted a lot of research interests, including applications as biological materials and devices. However, before SiNWs can be incorporated into new and existing biomedical devices, their cytotoxicity and their potential adverse effects on biological systems should be thoroughly investigated. Herein, we report the first study on the cytotoxicity of SiNWs to HepG2 cells and its effect on cell adhesion and spreading.

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Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 20, 2007
Pages: 426 - 429
Industry sector: Advanced Materials & Manufacturing
Topic: Advanced Materials for Engineering Applications
ISBN: 1-4200-6182-8