Shin D.C., Jang J.Y., Yang J-Y, Kim C.S., Kim S-H, Choi I.H., Lim Y.W., Kim C.S., Kim S-H, Lee G.T.
Yonsei University, KR
Keywords: Ag, apoptosis, Carbon Nanotube (CNT), cytokine, silver, viability
This study was undertaken to address the current deficient knowledge of cellular response to nano sized particle exposure.[4] The aim of this study was to investigate the in vitro responses of human bronchial epithelial cells (BEAS-2B) after exposure to nano-materials (Ag and CNT). BEAS-2B cell viability decreased with decreasing doses of Ag (diameters : 40~70 and 100 nm) and MWCNT (diameters : 4~6 and 10~15 nm) nano-materials. At the higher exposure ( 200 ug/ml), all materials induced significant cell damage. Nano Ag materials increased apoptosis and cytokine expression (IL-6 and IL-8) when over 100 ug/ml concentration. All MWCNTs weakly increased apoptosis and did not significantly increased cytokine expression. In conclusion, we suggest that Ag and MWCNT nano-materials induce variable extents of cellular toxicity in a dose-dependent and size-dependent.
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Pages: 142 - 145
Industry sectors: Advanced Materials & Manufacturing | Personal & Home Care, Food & Agriculture
Topic: Environmental Health & Safety of Nanomaterials
ISBN: 978-1-4200-8504-4