Continuous Separation of Non-Magnetic Particles through Negative Magnetophoresis inside Ferrofluids

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We present a simple, effective and label-free continuous flow non-magnetic microparticle separation scheme in a microfluidic device under static magnetic fields. The separation process is based on negative magnetophoresis and uses water-based ferrofluids. We exploit the difference in particle sizes to achieve continuous binary separation of fluorescent microparticles. The prototype device demonstrates high throughput separation of 2 µm and 10 µm particles with close to 100% separation efficiency. This new approach opens the door for the development of label-free particle and cellular separation in microfluidic devices with high throughput, efficiency and reliability.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2010: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational
Published: June 21, 2010
Pages: 436 - 441
Industry sector: Sensors, MEMS, Electronics
Topics: Micro & Bio Fluidics, Lab-on-Chip
ISBN: 978-1-4398-3402-2