Erdos G.W., Moraga D., Palazuelos M., Powers K.
University of Florida, US
Keywords: apoptosis, electron microscopy, lysosomes, toxicology
Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak cytochrome-c which begins a process leading to apoptotic cell death.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Pages: 78 - 80
Industry sector: Medical & Biotech
Topic: Biomaterials
ISBN: 0-9767985-0-6