Prina-Mello A., Diao Z., Coey J.M.D.
CRANN Research Laboratory, IE
Keywords: cell alignment, cell separation, magnetism, nanowires
In this paper we investigate the possibility of using magnetic nanowires in cell separation and manipulation. Ni, Co/Cr and Co/Fe nanowires made by electrochemical deposition in anodic aluminum oxide (AAO) templates. The combination between nanowires and different cells such as MC3T3 mouse fibroblasts, UMR-106 has been shown. There, cell viability with all the three kinds (Ni, Co/Cr and Co/Fe) of nanowires after combination was monitored. Magnetic cell separations were carried out following standardized conditions have achieved 75% purity and 75% yield.
Moreover, we were also successful in aligning the nanowires with cells in a 0.1 T uniform magnetic field. There, the axial of the magnetic nanowires internalised into cells can be aligned to the field direction with uniform magnetic field.
Therefore, a cell-nanowire interaction and living study will be addressed in the future in order to understand the intrinsic mechanisms responsible for cell internalization and alignment.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 7, 2006
Pages: 62 - 63
Industry sector: Advanced Materials & Manufacturing
Topic: Nanoelectronics
ISBN: 0-9767985-6-5