zebrafish – TechConnect Briefs

Development of In-Vivo Screening Benchmarks for Complex Engineered Nanomaterials

Mahoney S., Najera M., Bai Q., Burton E., Veser G., University of Pittsburgh, US

This works investigates embedding metal nanoparticles (NPs) in porous silica shells to reduce or entirely mitigate the metal NPs toxicity while still providing access to the metal NP surface; hence maintaining functionality of the embedded [...]

Bio-compatibility of silver nanomaterials using the embryonic zebrafish bioassay

Fisher J.A., Tanguay R.L., Oregon State University, US

The bio-compatibility of silver nanomaterials (AgNP) is currently of great interest to regulators and health and safety professionals because it is a material that has the potential to reach mass populations. Four well characterized (Harper [...]

Toxicological effects of functionalized single-walled carbon nanotubes (SWCNTs) on embryonic zebrafish (Danio rerio)

Felix L., Martinez-Rubi Y., Simard B., Goss G., University of Alberta, CA

Since their discovery in 1993, single-walled carbon nanotubes (SWCNTs) have played an integral role in nanotechnology and have been extensively studied due to their unique structural, electrical and mechanical properties. Chemical functionalization and coating of [...]

Zebrafish as a universal in vivo model for plasmonic nanoparticle medicine

Lukianova-Hleb E., Santiago C., Wagner D., Hafner J., Lapotko D., Rice University, US

In vivo application of plasmonic methods faces serious challenges because standard animal models are not well suited for optical activation and detection of plasmonic effects and for precise control the distribution and interactions of the [...]

Biodistribution and Toxicity of Nanomaterials In Vivo: Effects of Composition, Size, Surface Functionalization and Route of Exposure

Harper S.L., Maddux B., Hutchison J., Tanguay R.L., Oregon State University, US

Given the anticipated growth of the nanotechnology industry and the deficiency of toxicological information, there is an obvious need for rapid, relevant and efficient testing strategies to evaluate the biological activity and toxic potential of [...]

Toxicogenomics study of nanomaterials on the model organism zebrafish

Rojo I., Uriarte M., Obieta I., Bustero I., Egizabal A., Pardo M.A., Martínez de Ilárduya O., Azti-Tecnalia, ES

The applications of nanomaterials include fields as biomedicine, cosmetics or food science, raising a concern about the need to determine their toxic effects. Most of the toxicity tests are based on the analysis of classical [...]