tumor imaging – TechConnect Briefs

A Metallofullerene Nanoparticle Platform for Imaging and Treatment of Glioblastoma Multiforme Tumors

Dorn H.C., Zhang J., Fatouros P., Shultz M.D., Wilson J.D., Virginia Polytechnic Institute and State University, US

Glioblastoma multiforme (GBM) brain tumors occur as masses with infiltrative margins that are extremely invasive. GBMs result in a high recurrence rate with a poor prognosis for patients who are newly diagnosed with only an [...]

Development of peptide conjugated Superparamagnetic Iron Oxide (SPIO) Nanoparticles for Targeted MR Imaging and Therapy of Pancreatic Cancer

Yang L., Mao H., Cao Z., Wang A., Wang X., Peng X., Wang A., Wang X., Karna P., Adams G., Yuan Q., Staley C., Wood W.C., Nie S., Gao X., Emory University, US

We have engineered superparamagnetic iron oxide (IO) nanoparticles targeted to urokinase plasminogen receptors (uPAR), which is highly expressed in tumor cells, intratumoral fibroblasts and tumor endothelial cells and can also be internalized by cells. IO [...]

Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI

Sun C., Veiseh O., Kohler N., Gunn J., Lee D., Sze R., Hallahan A., Zhang M., University of Washington, US

Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method [...]