toxicogenomics – TechConnect Briefs

In vitro Model for Identifying Subchronic Carbon Nanotube Exposure and Lung Cancer Gene Markers

Stueckle T., Davidson D., Derk R., Meighan T., Castranova V., Rojanasakul Y., Wang L., National Institute for Occupational Safety and Health, US

Concern for increased risk of carbon nanotube-associated lung disease, including carcinogenesis, has been raised due to asbestos-like characteristics. To date, no particle specific nanomaterial exposure or lung cancer markers have been identified. Here, we use [...]

Toxicogenomics study of nanomaterials on the model organism zebrafish

Rojo I., Uriarte M., Obieta I., Bustero I., Egizabal A., Pardo M.A., Martínez de Ilárduya O., Azti-Tecnalia, ES

The applications of nanomaterials include fields as biomedicine, cosmetics or food science, raising a concern about the need to determine their toxic effects. Most of the toxicity tests are based on the analysis of classical [...]

An OMICs Approach for Assessing the Safety of Single-Walled Carbon Nanotubes in Human Skin and Lung Cells

Cunningham M.J., Shah M., Lema C., Magnuson S., Falduto M., Balzano L., Resasco D., Houston Advanced Research Center, US

High-throughput OMICs biotechnologies combined with a systems biology approach were used to screen for the toxicity of nanomaterials. Profiling of the macromolecular interactions within human cells was done with mRNA and miRNA expression microarrays (genomics) [...]