thrombosis – TechConnect Briefs

Dex40-GTMAC3, modified dextran as a novel heparin antagonist

Kalaska B., Kaminski K., Sokolowska E., Czaplicki D., Kujdowicz M., Stalinska K., Szczubialka K., Bereta J., Pawlak D., Nowakowska M., Mogielnicki A., Medical University of Bialystok, PL

Protamine is the only registered antidote preventing bleeding of patients treated with unfractionated heparin (UFH). However protamine may induce anaphylactic shock or serious hypotension. We aimed to develop an alternative fully synthetic UFH antidote as [...]

Nonclinical evaluation of heparin binding copolymer – HBC1 for restoring of blood coagulation after heparin treatment

Kalaska B., Sokolowska E., Kaminski K., Miklosz J., Shin-ichi Y., Błazejczyk A., Wietrzyk J., Kasacka I., Szczubialka K., Pawlak D., Nowakowska M., Mogielnicki A., Medical University of Bialystok, PL

The incredible progress and wide use of various medical devices during intravascular or cardiac interventions increased the need for administration of anticoagulants, such as heparins. Protamine sulfate – a protein isolated from salmons is the [...]

New Applications of Nanoparticles in Cardiovascular Imaging

Sharma R.R., FAMU-FSU College of Engineering, US

Nanotechnology involves working at the atomic, molecular, and macromolecular levels including imaging. Recently, four areas have emerged in cardiovascular imaging:1.Targeted therapeutics: delivering drugs where they are needed; 2.Tissue engineering to replace defective valves, damaged heart [...]

Molecular Targeted Functional, Cellular and Molecular Imaging of Atherosclerosis with Antibody-conjugated Superparamagnetic Particles Using Magnetic Resonance

Sharma R., Katz J.K., Haik Y., Chen C-J., FAMU-FSU College of Engineering, US

Background: Magnetic Resonance Imaging (MRI) is a powerful non-invasive technique that provides high-resolution anatomical images of biological tssue based on their inherent physio-chemical properties. The signal from MRI can be modulated by contrast agents, which [...]