Simulation and synthesis of a self-assembling and tumor-targeted drug delivery system
Poly(styrene-alt-maleic anhydride) is an amphiphilic alternating copolymer that self-assembles into supramolecular nanotubes in aqueous, physiological-pH environments. Its 2nm hydrophobic inner diameter is stable in neutral pH solution but opens as pH drops. Folate-conjugated nanotubes could [...]