targeted gene delivery – TechConnect Briefs

Epidermal Growth Factor Receptor-Targeted Engineered Gelatin Nanovectors for Gene Delivery and Transfection

Magadala P., Amiji M., Northeastern University, US

Purpose: Over 80% of human pancreatic cancer expresses epidermal growth factor family of receptors on the cell surface. In this study, we have examined the potential of EGFR-targeted gelatin-based engineered nanovectors (GENS) for plasmid DNA [...]

Oral Macrophage Mediated Gene Delivery System

Soto E., Ostroff G., University of Massachusetts Medical School, US

The efficiency of non-viral gene delivery is dependent on 4 factors: DNA protection, DNA delivery across membranes, endosomal DNA release, and nuclear uptake. Here we report on the development of a new delivery technology based [...]