targeted drug delivery – TechConnect Briefs

Precise Phage-navigating Metastatic Breast Cancer-targeted Paclitaxel-Micell Nanomedicines

Petrenko V.A., Torchilin V.P., Auburn University, US

Breast cancer is one of the most common cancers in the USA. Despite the increase of relative survival rate of women with breast cancer for the last decades, it is still low (~26%, 5 years) [...]

Self-navigating drug delivery nanovehicles driven by polyvalent multifunctional phages and their promiscuous proteins

Petrenko V.A., Gillespie J.W., Auburn University, US

Development of precision medicines acting specifically at the site of disease has been a long sought goal for the last century, starting from pioneering works of Paul Ehrlich, who suggested the concept of site-directed chemotherapeutics [...]

Molecular toolkits for engineering of self-navigating drug delivery vehicles

Gillespie J.W., Auburn University, US

Analysis of multi-thousand clone populations of the cancer cell-binding landscape phages and their multi-motif proteins using massively parallel sequencing techniques allowed the discovering of a variety of short motifs serving as elementary binding units during [...]

An Integrated Biometric Platform for Evaluation of Targeted Drug Delivery

Liu Y., Thomas A., Uhl C., Wang S., He R., Lehigh University, US

In order to develop in vitro methods, which more closely resemble in vivo environments, a novel technology involving the use of microfluidic devices, which more closely mimic blood vessels has been developed. The technology has [...]

An Integrated Biometric Platform for Evaluation of Targeted Drug Delivery

Liu Y., Thomas A., Uhl C., Wang S., He R., Lehigh University, US

In order to develop in vitro methods, which more closely resemble in vivo environments, a novel technology involving the use of microfluidic devices, which more closely mimic blood vessels has been developed. The technology has [...]

Combined targeted hyperthermia and drug delivery with magnetic nanoparticles

Mitrelias T., Tselepi M., Barnes C., Orel V., Schepotin I., Cavendish NanoTherapeutics, UK

Cancer remains the second leading cause of deaths worldwide and in the U.S. alone every year there are over 1.5 million new diagnoses. Technologies that would allow targeted destruction of tumours by localising the delivery [...]

Nanomaterial: A realistic business case for Pharma

Keller T.H., GlaxoSmithKline, UK

Main points from a pharma perspective: Review nanotech’s current position Nanotech and its realistic potential Nanotech and the barriers into the clinic GSK’s position on the subject matter

New Highly Efficient Non-invasive Nanoparticulate Delivery Systems for the Treatment of Chronic Diseases

Sinner F.M., Institute of Medical Technologies and Health Management, Joanneum Research, AT

We herein report the overall goals of the joint project “Nano-Health” and preliminary results of two sub-projects (Nano-Health started in October 2004), which was positive evaluated by international reviewers within the first Call of the [...]