poly (lactic acid)-b-poly (ethylene glycol)

Sustained Release of Functional Interleukin-10 Encapsulated within Poly (lactic acid)-b-Poly (ethylene glycol) Nanoparticles Down-regulates Cytokines in Mouse Macrophages Exposed to Chlamydia trachomatis

Duncan S., Dixit S., Sahu R., Nyairo E., Singh S.R., Dennis V.A., Alabama State University, US

Inflammation which is induced by the presence of cytokines and chemokines is an integral part of Chlamydial infection. Chlamydia trachomatis (CT), the bacterial pathogen responsible for this sexually transmitted infection worldwide, causes severe inflammation including, [...]

PLA-PEG nanoparticles are suitable for effective maturation and uptake by dendritic cells for Chlamydia trachomatis outer membrane peptide-based vaccine

Dixit S., Sahu R., Singh S.R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is considered an important human pathogen because it is the most reported sexually transmitted bacterial infection globally. We showed that M278 (a peptide derived from the major outer membrane protein of C. trachomatis) [...]

Influence of Polyvinyl Alcohol (PVA) on Morphology and Encapsulation Efficiency of Polylactic Acid-Polyethylene Glycol (PLA-PEG) copolymer based Nanoparticle’s

Dixit S., Davis M.D., Singh S.R., Dennis V.A., Alabama State University, US

Polyvinyl alcohol is the most commonly used emulsifier in the formulation of NPs. Provides non-aggregating, emulsifying and adhesive properties to NPs and an interconnected network with the polymer at the interface which ultimately can affect [...]

Activation of antigen presenting cells and induction of mucosal antibodies by Chlamydia trachomatis outer membrane peptide encapsulated within PLA-PEG nanoparticles

Dixit S., Taha M., Singh S.R., Dennis V.A., Alabama State University, US

In pursuit of a vaccine against Chlamydia trachomatis, the most reported bacterial sexually transmitted infection, we previously reported that encapsulation of M278, a peptide derived from the major outer protein of C. trachomatis within PLA-PEG [...]

PLA-PEG as a delivery system for a Chlamydia trachomatis subunit vaccine

Dixit S., Singh S.R., Yilma A.N., Agee R., Dennis V.A., Alabama State University, US

We hypothesize that M287 encapsulated in PLA-PEG will provide for its slow controlled release and thus enhance its capacity to induce immune responses in mice.