phage display – TechConnect Briefs

Precise Phage-navigating Metastatic Breast Cancer-targeted Paclitaxel-Micell Nanomedicines

Petrenko V.A., Torchilin V.P., Auburn University, US

Breast cancer is one of the most common cancers in the USA. Despite the increase of relative survival rate of women with breast cancer for the last decades, it is still low (~26%, 5 years) [...]

Self-navigating drug delivery nanovehicles driven by polyvalent multifunctional phages and their promiscuous proteins

Petrenko V.A., Gillespie J.W., Auburn University, US

Development of precision medicines acting specifically at the site of disease has been a long sought goal for the last century, starting from pioneering works of Paul Ehrlich, who suggested the concept of site-directed chemotherapeutics [...]

Molecular toolkits for engineering of self-navigating drug delivery vehicles

Gillespie J.W., Auburn University, US

Analysis of multi-thousand clone populations of the cancer cell-binding landscape phages and their multi-motif proteins using massively parallel sequencing techniques allowed the discovering of a variety of short motifs serving as elementary binding units during [...]

The Detection of PETN Using a Bulk Single Wall Carbon Nanotube/Peptide System

Kubas G., Rees W., Caguiat J., Asch D., Fagan D., Cortes P., Youngstown State University, US

The present research work investigates the novel detection of pentaerythritol tetranitrate (PETN), a high powered explosive, using peptide surface functionalized single wall carbon nanotubes. Here, through the use of a phage display technique and enzyme-linked [...]

A Specific Surface-coating Peptide for Rare Earth Nanomaterials

Zhang Y.J., Zhou W., Wen L.P., University of Science and Technology of China, CN

The induction of autophagy on exposure of cells to a variety of nanoparticles represents both a safety concern and an application niche for engineered nanomaterials. Using phage display, we have discovered an 11-amino acid peptide [...]

Targeting Nanoparticle Probes to Differentiating Stem Cells

Cabral-Teixeira J., Benjamin K., Zhang L., Maurer J., Tsuda M., Chao Y.S., Prigozhina N., Price J., Snyder E., Mercola M., Ruoslahti E., West M.D., Larocca D., Advanced Cell Technology, US

Pluripotent stem cells offer great potential for treating diseases where cells are lost to injury or disease processes. The ability to specifically label progenitor cells in populations of differentiating stem cells will provide a powerful [...]

Phage-Derived Bioselective Nanovehicles for Drug and Gene Delivery

Petrenko V.A., Auburn University, US

Phage display technology rests on two fundamental concepts: combinatorial chemistry and fusion phage. We first demonstrated fusion of the major coat protein of the phage with foreign random peptides, which results in landscape phage libraries. [...]