PEG – TechConnect Briefs

Synthesis of Ultra Small Biocompatible Magnetic Nanocomposites by Seeded Emulsion Polymerization

Kloust H., Pöselt E., Kappen S., Schmidtke C., Kornowski A., Pauer W., Moritz H.-U., Weller H., University of Hamburg, DE

We present the production of PEGylated particles in the lower nanometer range by a new seeded emulsion polymerization technique under micro-emulsion conditions, avoiding any treatment with high shear forces or ultrasonication. Hereby, the hydrophobic shells [...]

Cytotoxic studies of PEG functionalized ZnO Nanoparticles on MCF-7 cancer cells

Rodriguez Martinez C., Ramirez Vick J.E., Perales O., Singh S.P., University of Puerto Rico-Mayagüez, US

Nanoparticles have shown great promise in biomedical applications. Zinc oxide (ZnO) nanoparticles are being explored for various applications such as sun screen lotion, antimicrobial properties, advanced textiles, photodynamic therapy and electronic devices. We have synthesized [...]

Redispersible hybrid nanopowders: cerium oxide nanoparticle complexes with phosphonated-peg oligomers

Qi L., Sehgal A., Castaing J.-C., Fresnais J., Berret J.-F., Chapel J.-P., Rhodia/CNRS joint Institution, US

Rare earth cerium oxide (ceria) nanoparticles are stabilized using end-functional phosphonated-PEG oligomers. The complexation process and structure of the resulting hybrid core-shell singlet nanocolloids are described, characterized and modeled using light and neutron scattering data. [...]

Modified AFM Probes for Nanoscale Biomolecular Recognition Studies

Johnson W.T., Agilent Technologies, US

Biomolecular interactions, which are responsible for many physiologically important processes, can be studied by molecular recognition force microscopy (MRFM). In MRFM, nanoNewton scale single molecule interactions are observed and quantified one by one as an [...]

Novel surface architectures for biomimetic lipid membranes

Reimhult E., Merz C., Ye Q., Textor M., Swiss Federal Institute of Technology (ETH Zürich ), CH

Many important biological processes occur at, via or across one of the various lipid membranes present in the cell. These include transport governed by transmembrane proteins constituting more than 50% of all drug targets of [...]

A Behavior of Protein Adsorption on Poly(Ethylene Glycol)-Modified Surfaces under Flow Conditions at Relatively Low Concentrations for Microfluidics Systems

Chun C-J, Lenghaus K., Riedel L., Bhalkikar A., Hickman J.J., University of Central Florida, US

Microfabrication technology has been used to create new microfluidics systems for bioanalytical and medical device applications in the last decade. The handling of relatively small amounts of analytes, at significantly lower concentrations, combined with the [...]

Hetero-bifunctional Poly(ethylene glycol) Modified Gold Nanoparticles as an Intracellular Tracking and Delivery Agent

Fu W., Shenoy D., Li J., Crasto C., Jones G., Dimarzio C., Sridhar S., Amiji M., Northeastern University, US

To increase the targeting potential, circulation time, and the flexibility of surface-attached biomedically-relevant ligands on gold nanoparticles, hetero-bifunctional poly(ethylene glycol) (PEG, MW 1,500) was synthesized having a thiol group on one terminus and a reactive [...]

Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI

Sun C., Veiseh O., Kohler N., Gunn J., Lee D., Sze R., Hallahan A., Zhang M., University of Washington, US

Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method [...]