PAMAM dendrimers – TechConnect Briefs

Celastrol-Based Nanomedicines as Modulators of Neuroinflammation

Boridy S., Hutter E., Soliman G., Maysinger D., McGill University, CA

Chronic inflammation plays a pivotal role in promoting disease pathology in the central nervous system (CNS). Microglial cells are the main innate immune effector cells in the CNS and orchestrate these neuroinflammatory reactions that ultimately [...]

Mechanistic studies of in vitro cytotoxicity of PAMAM dendrimers in mammalian cells

Mukherjee S.P., Lyng F.M., Garcia A., Davoren M., Byrne H.J., Focas Research Institute, Dublin Institute of Technology, IE

The in vitro cytotoxic response of human dermal and colon cell lines to structurally well-defined full generation cationic dendritic polyamidoamine (PAMAM) nanoparticles of generations G4, G5, G6 was investigated. PAMAM dendrimers have been demonstrated to [...]

Interaction of Polyamido-amine (PAMAM) nanoparticles with the glassy carbon supported bilayer lipid membrane

Jadhav S.R., Mark Worden R., Michigan State University, US

Polyamido-amine (PAMAM) dendrimers are hyperbranched polymers with uniform particle size making them ideal monodisperse nanoparticles. PAMAM dendrimers are being pursued as non-viral vectors for gene delivery due to their low immunogenicity and their ability to [...]