microfluidic device – TechConnect Briefs

Microfluidic Control of Adipose-Derived Stem Cell Growth and Positioning

Wadhawan N., Kalkat H., Ma X., Gajjeraman S., Nandagopal S., Hao N., Deng J., Xiang B., Zhang M., Tian G., Lin F., University of Manitoba, CA

Microfluidic devices provide powerful new tools for quantitative stem cell research owing to its advantages in cellular microenvironmental control and experiment throughput over conventional methods. Particularly, microfluidics is playing a growing role in studying stem [...]

Nanofluidic Channel Based Single Molecular Sensors in Polymer Substrate Fabricated by Novel Nanoimprinting Processes

Wu J., Chantiwas R., Soper S.C., Park S., Louisiana State University, US

One critical challenge in developing innovative nanochannel-based sensors for bio/chemical analyses is to build multiscale structures composed of narrow, long and continuous fluidic nanochannels and microfluidic networks at low cost. We presents a novel process [...]

Amperometric glucose sensor for real time extracellular glucose monitoring in microfluidic device

Ges I.A., Baudenbacher F.J., Vanderbilt University, US

Glucose and lactate are the most important metabolites which characterize physiological state and the metabolic activity of living cells. Consequently, development of a stable glucose biosensor is an interesting and important research topic for medicine [...]

Investigation of pH behavior of single myocyte cells in picoliter microfluidic device

Ges I.A., Baudenbacher F.J., Vanderbilt University, US

The possibility to investigate single cell metabolic activity in real time in sub-nanoliter volume could expand our knowledge of cellular physiological processes. Extracellular pH is a critical parameter for many cellular processes and extracellular acidification [...]

Integrated Microfluidic Device with an Electroplated Palladium Decoupler for Electrochemical Detection of the 8-hydroxydeoxyguanosine (8-OH-dG) DNA Adduct

Dawoud A.A., Kawaguchi T., Jankowiak R., Iowa State University, US

More sensitive and reliable microfluidic devices are needed for the detection of the 8-hydroxy-deoxyguanosine (8-OH-dG) DNA adduct, one of the most frequently used biomarkers reporting on oxidative stress. Therefore, we have developed a capillary electrophoresis [...]

Integrated microfluidic device to monitor the cells acidification rate in nanoliter volumes using microfabricated iridium oxide electrodes

Ges I.A., Ivanov B.L., Baudenbacher F.J., Vanderbilt University, US

In our work we describe a new approach to measure pH differences in microfluidic devices and demonstrated acidification rate measurements in on-chip cell culture systems with nanoliter wells. We used two miniaturized identical iridium oxide [...]

Direct Write Technology as a Tool to Rapidly Prototype Patterns of Biological and Electronic Systems

Ringeisen B.R., Chrisey D.B., Piqué A., Krizman D., Brooks M., Spargo B., Naval Research Laboratory, US

The full potential of modeling and simulations is only realized when it is based on experimental results under varied conditions and systems. A single tool to rapidly prototype electronic and biological circuits would enhance the [...]