lung cancer – TechConnect Briefs

Lipopolymeric nanoparticles: platform technology for aerosolized combination chemotherapy

Kaur S., Banerjee R., Indian Institute of Technology - Bombay, IN

In the present study, we have conceptualized and formulated a novel delivery vehicle which includes a combination of lipid nanovesicles and polymeric nanoparticles. Main aim of the study is to devise a nanoscale platform technology [...]

Dielectrophoretic characterization and separation of metastatic variants of small cell lung cancer cells

Menachery A., Burt J., Chappell S., Errington R.J., Morris D., Smith P.J., Wiltshire M., Furon E., Pethig R., Bangor University, UK

In this study, the ability of Dielectrophoresis (DEP) to recognize phenotypic variants of small cell lung cancer (SCLC) cells has been tested. The phenotypic variations of the SCLC cells are associated with the cell-surface decoration [...]

Establishing a GMP manufacturing site for nanoparticles

Sepulveda C.A., Roth J.A., Lu C., Ji L., Ramesh R., O’Connor S., Sadeghi T., Flagge F., Baez O., Shen A.C., Mondesir E., Jenkins J., Shpall E., McMannis J.D., University Texas MD Anderson Cancer Center, US

An active clinical trial at MD Anderson Cancer Center uses DOTAP:Chol liposomes as a non-viral vector for gene therapy. This therapeutic product needs to be produced fresh for each administration. Originally, the manufacture of the [...]