hyaluronic acid – TechConnect Briefs

Characterisation of THP-1 macrophages as an in vitro model for CD44-targeted therapies

M. Rios de la Rosa J., Tirella A., Gennari A., Tirelli N., University of Manchester, UK

CD44 is the major cell surface receptor of hyaluronic acid (HA) and mediates the response of cells to their cellular microenvironment. Whereas the standard isoform (CD44s) is ubiquitously expressed throughout the body, variant isoforms (CD44v) [...]

HA-decorated nanoparticles as tumour-targeting nucleic acids carriers

Tirella A., Rios J.M., Tirelli N., University of Manchester, UK

The design of tools that allow for a targeted delivery of therapeutic cargos have a great potential in the treatment of many pathological conditions (e.g. cancer and autoimmune diseases). In the context of nucleic acids [...]

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular deliery of doxorubicin

Saravanakumar G., Shin J.M., Um W., Park J.H., Sungkyunkwan University, KR

Disulfide-containing HA dodecyl conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction as the carrier for intracellular delivery of doxorubicin (DOX). Owing to its amphiphilicity, HA-SS-DDT could form self-assembled nanoparticles in an aqueous condition. The [...]

The effect of Simvastatin Acid Loaded Photocurable Hyaluronic Acid Hydrogel for Bone Regeneration In vitro and In vivo

Bae M.S., Kim S.E., Na J.S., Kwon I.K., School of Dentistry, Kyung Hee University, KR

In the field of bone tissue engineering, various biomaterials have been developed in conjugation with bone inducing factors for bone tissue regeneration due to their distinct activities of osteoconductivity and osteoinductivity. In this study, we [...]