drug delivery – Page 6 – TechConnect Briefs

Controlling pH responsive polymersome assembly

Pearson R., Battaglia G., University of Sheffield, UK

Size is an important parameter in delivery systems. It plays a part in whether a particle avoids filtration, evades immune cell binding and by which internalisation pathways are available. However, it is hard to obtain [...]

Novel mesoporous silicon particles as an efficient sustained delivery system for antibiotics

Yazdi I., Chiappini C., Weiner B., Ferrari M., Tasciotti E., The University of Texas Health Science Center at Houston, US

Delivery systems able to release antibiotics over an extended period of time can solve all these issues and provide efficacious alternative solutions to the current approaches. The ultimate objective of this study is to prove [...]

Delivery of Camptothecin to Cancer Cells with Silica Nanoparticles

Botella P., Abasolo I., Muniesa C., Ruiz J., Fernández Y., Quesada M., Corma A., Schwartz Jr. S., Instituto de Tecnologia Quimica (UPV-CSIC), ES

We present a novel and robust delivery platform for camptothecin (CPT) based in silica nanoparticles (SNP) of 5-15 nm diameter that transport the drug attached by ester bond in 20-OH position. The surface of these [...]

Water Soluble Carotenoid Conjugates with Oligo- and Polysaccharides. Synergy of Drug Transport and Efficacy

Polyakov N.E., Leshina T.V., Meteleva E.S., Dushkin A.V., Konovalova T.A., Kispert L.D., University of Alabama, US

We present first example of water soluble conjugates of carotenoids with a triterpene glycoside, glycyrrhizic acid (GA), and natural polysaccharide arabinogalactan (AG), studied by various physicochemical techniques. Carotenoids are well known as a class of [...]

Agarose coating improves protein stability during sustained release

De Rosa E., Yadzi I., Liu X., Ferrari M., Tasciotti E., UT HSC Houston, US

The advances in drug-delivery systems over recent decades highly improved the effectiviness of drug administration. Biocompatible, biodegradable porous silicon microparticles stable can be modified to provide controlled release and enhanced stability of the loaded/encapsulated bioactive [...]

Magnetoliposomes: Stability of Magnetic Nanoparticles in Suspension for drug delivery

Sen T., Sheppard S.J., Mercer T., Elhissi A., University of Central Lancashire, UK

A simple and rapid one pot method of synthesis of magneto-liposome has been reported. The nanoparticles exhibited exceptional stability in suspension. Magnetoliposomes were efficient for DNA binding/elution and drug loading.

Thermoresponsive Magnetic Micelles for Simultaneous Magnetic Hyperthermia and Drug Delivery

Kim D-H., Elena R., Rajh T., Bader S.D., Novosad V., Argonne National Laboratory, US

Hyperthermia has been shown to be a potentially effective therapeutic modality in cancer treatment as it intensifies the efficacy of chemotherapy. The hyperthermia has a good synergic effect with chemotherapy. Their sensitivity to chemotherapy after [...]

Mechanism of Nitroimidazole Coated Magnetic Nanoparticles Embedded in Micro-organisms as Delivery Systems

Goel N., Sharma R., Post Graduate Institute of Medical Science, IN

Avirulent Bacteria and parasites act as “tiny missile like carriers” capable to carry the magnetic nanoparticles (NMP) together with anticancer or radiosensitizer drugs at the tumor site. We compared the iron-oxide particles binding characteristics with [...]

Epirubicin hydrochloride loaded poly (butyl cyanoacrylate) nanoparticles: formulation optimization, characterization and in vitro evaluation on human breast cancer cell lines

Dantuluri P.R., Shah N.M., Murthy R.S.R., Kumar M.R.S., Rao B.S.S., The M.S. University of Baroda, IN

Breast cancer is the second leading cause of deaths in women today after lung cancer, the mortality rate of patients with breast cancer around the world is rising steadily over time. Metastatic spread is the [...]

Role of Ultrasound in Anti-Cancer Drug Delivery Loaded on Microspheres

Mohamed M.M., El belbese M.A., Kotb M.A., Fikry N.M., Ramadan H.S., Alexandria University, EG

Targeting is a new therapeutic tool for malignant tumor as a result of combining nanotechnology with chemotherapeutics. Ultrasound has been shown to enhance degradation and drug delivery from biodegradable and non biodegradable polymeric devices. If [...]