drug delivery – Page 2 – TechConnect Briefs

Fabrication of Conductive Nanoporous Membranes using Self-Assembling Block for Electrically Controlled Diffusive Flow

Ozalp E.I., Kim S., Sundar V., Zhu J.-G., Weldon J.A., Carnegie Mellon University, US

Nanoporous membranes have been recognized as promising candidates for drug delivery applications due to their small pore size and high surface-to-volume ratio1. The ultimate goal of smart drug delivery systems is to release a specific [...]

Acne Treatment based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Gold Plasmonic Particles

Paithankar D., Meyer T., Blomgren R., Faupel L., Lando A., Anderson R., Sebacia, Inc., US

A laser treatment for acne, one of the most common dermatologic conditions, with 150 nm diameter plasmonic resonant particles tuned to absorb near infrared light has been developed. Acne lesions originate from sebaceous follicles; the [...]

Dependence of the Energy of Electric Pulse Required to Electroporate the Cell on the Pulse Duration for Pulses from 50 ns to 500 ms

Saulis G., Bitinaitė A., Vytautas Magnus University, LT

To successfully implement the technology of food processing with pulsed electric fields (PEF), it is important to know what particular electric treatment (pulse duration, field strength, etc.) would require the minimum energy. Here, theoretical relationships [...]

Novel method for topical and transdermal delivery of Nanomaterials

Kalghatgi S., Juluri A., Stone S., Gray R., EP Technologies LLC, US

Nanoscale drug delivery systems including, but not limited to nanoparticles, liposomes, nanotubes, quantum dots, could potentially revolutionize modern drug delivery systems. Nanomaterials have wide applications in pharmaceutical sciences including their use in drug delivery as [...]

Skin permeation of hydrophobic drugs loaded into polymeric nanoparticles

Feitosa V.A., Balogh T.S., Guimarães K.L., Zanin M.H.A., Oliveira A.M., Cerize N.N.P., Institute for Technological Research – IPT, BR

Polymeric nanoparticles have been employed for topical pharmaceutical applications due to its capacity to carry drugs across the skin. Biocompatible polymers are extensively applied as coating nanoparticles allowing them present controlled physical and chemical characteristics. [...]

Folic Acid Conjugated Polymer as a New Active Tumor Targeting Drug Delivery Platform

Li X., Szewczuk M.R., Malardier-Jugroot C., Royal Military College of Canada, CA

Nanotechnology has been extensively exploited to improve conventional cancer therapy in the recent years1. The designed nanocarriers allow drug to be delivered to cancer cells specifically with prolonged circulation time and controlled drug release2–4. In [...]

nPortTM Platform Nanotechnology for Liposome Manufacturing:from 20 to 200nm and from Micrograms to Kilograms

Zhu D.M., Chen G.Q., Cureport, Inc., US

Liposome-based drug delivery is one of the clinically advanced technologies for the treatment of human cancer and severe infectious disease.It improves pharmacokinetics, reduces toxicity, and enhances efficacy of the drugs. The complex manufacturing process, poor [...]

Oxidized Graphene Nanoribbons as a Delivery System for the Bioactive Sphingolipid Ceramide

Suhrland C., Truman J.P., Sitharaman B., Stony Brook University, US

Dysregulation of the metabolic pathways of the sphingolipid ceramide has been shown to play key roles in cancer cell proliferation and survival. Targeting these pathways with exogenous modulators of ceramide metabolism such as the short [...]

A New and versatile method for preparing crystalline drug nanoparticle formulations

Higgins J.D., Merck Research Labs, US

The birth of the nanoparticle (nanos) drug delivery field arguably was seen over 20 years ago with the advent and application of simple oral crystalline nanoparticle formulations. This effective approach for enhancind oral absorption using [...]

Thermally responsive lipid coated superparamagnetic nanoparticles for frequency triggered drug delivery

Patil-Sen Y., Eizadi Sharifabad M., Mercer T., Bond G., Patil-Sen Y., Sen T., University of Central Lancashire, UK

In this abstract, we report a series of novel thermally responsive lipid coated core-shell mesoporous silica-superparamagnetic iron oxide nanoparticles as drug delivery vehicles for potential use for cancer therapy under magnetic hyperthermia. Hydrophilic anticancer drug [...]