doxorubicin – TechConnect Briefs

Application of superparamagnetic nanoparticles for magnetically guided release of anti-cancer drug: An Ivvivo study on Rats

Choubey J., Swami M., Rani Durgawati Vishwavidyalya, Jabalpur, IN

By using appropriate magnetic parameters, 50-80% of the injected nanoparticles could be targeted, thus eliminating systemic distribution and subsequent toxicity of the entrapped agent. In this report we present data on the use of magnetic [...]

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular deliery of doxorubicin

Saravanakumar G., Shin J.M., Um W., Park J.H., Sungkyunkwan University, KR

Disulfide-containing HA dodecyl conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction as the carrier for intracellular delivery of doxorubicin (DOX). Owing to its amphiphilicity, HA-SS-DDT could form self-assembled nanoparticles in an aqueous condition. The [...]

Water-borne Polymeric Nanoparticles for Glutathione-Mediated Intracellular Delivery of Anticancer Drugs

Grimaldi N., università degli studi di palermo, IT

A new family of water-borne, biocompatible and carboxyl-functionalized nanogels (NGs) was developed for glutathione-mediated delivery of anticancer drugs. Nanogels were generated by e-beam irradiation of aqueous solutions of a crosslinkable polymer. Molecular structure and topology [...]

Multi-functional micelles for the combination of chemotherapy and radiotherapy in hepatocellular carcinoma

Shih Y-H, Peng C.L., Luo T-Y, Shieh M.J., National Taiwan University, TW

Hepatocellular carcinoma is the third leading cause of cancer deaths in worldwide. In this study, multi-functional micelles loaded with doxorubicin (Dox) and labeled with the radionuclide rhenium-188 (188Re) were developed to provide the combination of [...]

Supermagnatic Iron Oxide Nanoparticles Toxicity to Mammalian Cells

Vig K., Tiwari P., Parveen A., Rangari V., Singh S.R., Alabama State University, US

The present study investigates the development of superparamagnetic iron oxide nanoparticles as a controlled release drug formulation and use as anticancer therapeutic agents. Iron oxide nanoparticles (IONPs) were synthesized using ultrasonic irradiation of iron pentacarbonyl [...]

Enhanced Cytotoxicity of Doxorubicin Conjugated to Ultrasmall Au Nanoparticles

Zhang E., Ntumba K., Nadeau J., McGill University, CA

In this study we find that ultra-small (mean diameter, 2.8 nm) Au nanoparticles conjugated to doxorubicin (Au-Dox) are up to five-fold more cytotoxic to B16 melanoma cells than Dox alone. The particles enter the cell [...]

Preparation and investigation of biological activity of thermosensitive liposomes loaded with doxorubicin

Tazina E.V., Polozkova A.V., Orlova O.L., Ignatieva E.V., Mescherikova V.V., Wainson A., Yarmonenko S.P., Oborotova N.A., N.N.Blokhin Russian Cancer Research Center of RAMS, RU

Purpose: Preparation of thermoliposomes with doxorubicin and investigation of their effect on solid Ehrlich carcinoma and B-16 mouse melanoma in combination with hyperthermia. Materials and methods: Thermosensitive liposomes were prepared using DPPC, DSPC, DSPE-PEG 2000 [...]

Multiwalled Carbon Nanotube-Doxorubicin Supramolecular Complexes for Cancer Therapeutics

Ali-Boucetta H., Al-Jamal K.T., Kostarelos K., The School of Pharmacy, University of London, UK

The field of drug delivery is being revolutionised by the discovery of novel nanomaterials such as carbon nanotubes (CNTs) capable of traversing the plasma membrane and promoting the cellular uptake of small molecules and macromolecules [...]

Mechanism of Action and Surfactant Influence During Chemotherapy of Brain Tumour Using Doxorubicin-Loaded Poly(Butyl Cyanoacrylate) Nanoparticles

Petri B., Bootz A., Khalanski A., Hekmatara T., Müller R., Kreuter J., Gelperina S., Moscow Medical Academy, RU

Polysorbate 80(Tween® 80)-coated poly(butyl cyanoacrylate) nanoparticles have been shown to enable the transport of doxorubicin (DOX) across the blood-brain barrier (BBB). This formulation produced a high antitumoral effect in an orthotopic model of the very [...]

Temperature-Triggered Nanotechnology for Chemotherapy: Rapid Release From Lysolipid Temperature-Sensitive Liposomes

Mills J.K., Needham D., Duke University; presently Sterne, Kessler, Goldstein & Fox, P.L.L.C., US

Despite advances in drug retention and evasion of the body’s defenses, the therapeutic efficacy of many liposomes has been limited by low drug bioavailability within the tumor. Developed in this laboratory in 1996, lysolipid temperature [...]