Preparation and investigation of biological activity of thermosensitive liposomes loaded with doxorubicin

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Purpose: Preparation of thermoliposomes with doxorubicin and investigation of their effect on solid Ehrlich carcinoma and B-16 mouse melanoma in combination with hyperthermia. Materials and methods: Thermosensitive liposomes were prepared using DPPC, DSPC, DSPE-PEG 2000 [...]

Mechanism of Action and Surfactant Influence During Chemotherapy of Brain Tumour Using Doxorubicin-Loaded Poly(Butyl Cyanoacrylate) Nanoparticles

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Polysorbate 80(Tween® 80)-coated poly(butyl cyanoacrylate) nanoparticles have been shown to enable the transport of doxorubicin (DOX) across the blood-brain barrier (BBB). This formulation produced a high antitumoral effect in an orthotopic model of the very [...]