contrast agent – TechConnect Briefs

Nephrotoxicity of Dextran Functionalized Graphene Nanoparticles and Their Potential as Magnetic Imaging Contrast Agents for Renal Abnormalities

Lee S., Kanakia S., Toussaint J., Kukarni P., Chowdhury S.M., Khan S., Shroyer K., Moore W., Sitharaman B., Stony Brook University, US

Contrast-enhanced magnetic resonance angiography (MRA) employs the use of blood pool contrast agents (CA) such as gadolinium (Gd3+) complexes that allow for delayed phase arterial and venous imaging and improve the sensitivity in detecting small [...]

Development of Nanoparticle-Based Gold Contrast Agent for Photoacoustic Tomography

Yang Y.-S., Vaithilingam S., Ma H.T.-J., Khuri-Yakub B.T., Guccione S., Stanford University, US

Photoacoustic tomography (PAT) utilizes non-ionizing energy to obtain structural/functional information with high spatial resolution and sensitivity. Heterogeneous absorption of optical energy in biological tissues results in differentially expressed acoustic signals yielding spatial/temporal information. A critically [...]

Microscopic Mechanism of Sonoporation

Prentice P.A., Burns J.M., Cuschieri A., Campbell P.A., University of Dundee, UK

This paper will expand on our recent paper in Nature Physics (November 2005) and will show that the initial observations can be extended from rigid albumin systems to flexible lipid based microbubbles also. We will [...]

In Vivo Tracking of Liposomes Using CT and MR Imaging

Zheng J., Liu J., Jaffray D.A., Allen C., University of Toronto, CA

Currently, there are limited methods available for longitudinal and non-invasive in vivo assessment of the transport kinetics of carrier-based therapeutics, such as those relying on liposomes. A viable strategy to non-invasively track the carrier in [...]

Modelling the Microscopic Mechanisms of Sonoporation

Burns J.M., Prentice P.A., Cuschieri A., Campbell P.A., University of Dundee, UK

This work constitutes a theoretical follow up to our earlier paper in Nature Physics (November 2005) in which we demonstrate that, in the high amplutude limit, ultrasound stimulated microbubble cavitation behaviour can be approximated without [...]

Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI

Sun C., Veiseh O., Kohler N., Gunn J., Lee D., Sze R., Hallahan A., Zhang M., University of Washington, US

Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method [...]