Chlamydia trachomatis – TechConnect Briefs

Physio-structural and immunological characterization of a PLGA 85/15 encapsulated Chlamydia recombinant MOMP nanovaccine candidate

Sahu R., Dixit S., Singh S.R., Dennis V.A., Alabama State University, US

The quest for vaccine development against Chlamydia trachomatis (CT), the leading cause of bacterial sexually transmitted diseases worldwide, has escalated to reduce its occurrence and global economic burden. Recently, nanovaccines have emerged as attractive candidates [...]

Sustained Release of Functional Interleukin-10 Encapsulated within Poly (lactic acid)-b-Poly (ethylene glycol) Nanoparticles Down-regulates Cytokines in Mouse Macrophages Exposed to Chlamydia trachomatis

Duncan S., Dixit S., Sahu R., Nyairo E., Singh S.R., Dennis V.A., Alabama State University, US

Inflammation which is induced by the presence of cytokines and chemokines is an integral part of Chlamydial infection. Chlamydia trachomatis (CT), the bacterial pathogen responsible for this sexually transmitted infection worldwide, causes severe inflammation including, [...]

PLA-PEG nanoparticles are suitable for effective maturation and uptake by dendritic cells for Chlamydia trachomatis outer membrane peptide-based vaccine

Dixit S., Sahu R., Singh S.R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is considered an important human pathogen because it is the most reported sexually transmitted bacterial infection globally. We showed that M278 (a peptide derived from the major outer membrane protein of C. trachomatis) [...]

Activation of antigen presenting cells and induction of mucosal antibodies by Chlamydia trachomatis outer membrane peptide encapsulated within PLA-PEG nanoparticles

Dixit S., Taha M., Singh S.R., Dennis V.A., Alabama State University, US

In pursuit of a vaccine against Chlamydia trachomatis, the most reported bacterial sexually transmitted infection, we previously reported that encapsulation of M278, a peptide derived from the major outer protein of C. trachomatis within PLA-PEG [...]

Poly-Vinyl Pyrrolidone (PVP)-coated Silver (Ag) Nanoparticles (Ag-PVP): a Potential to Regulate Chlamydia trachomatis Inflammation

Yilma A.N., Singh S.R., Dixit S., Hidat G.G., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is an important cause of sexually transmitted infection that can manifest itself as either acute cervicitis, pelvic inflammatory disease, and more commonly as a chronic asymptomatic infection. Previously we reported Ag-PVP (5-10 nm) [...]

PLA-PEG as a delivery system for a Chlamydia trachomatis subunit vaccine

Dixit S., Singh S.R., Yilma A.N., Agee R., Dennis V.A., Alabama State University, US

We hypothesize that M287 encapsulated in PLA-PEG will provide for its slow controlled release and thus enhance its capacity to induce immune responses in mice.

Smaller sizes of Ag-PVP Nanoparticles Control Inflammatory Responses, and Reduce CD80 and CD86 Expression Levels, in Macrophages Infected with Chlamydia trachomatis

Yilma A.N., Singh S.R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is an important cause of sexually transmitted infection that can manifest itself as either acute cervicitis, pelvic inflammatory disease, and more commonly as a chronic asymptomatic infection. Early intervention strategies that can reduce [...]

Evidence of the Anti-inflammatory effect of Silver- polyvinyl Pyrrolidone Nanoparticles (Ag-PVP) in Chlamydia trachomatis infected Macrophages and HeLa Cells

Yilma A.N., Singh S.R., Murtada T.A., Fairley S., Subbarayan P., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is the leading cause of bacterial sexually transmitted diseases (STDs) in the USA, and therefore, of major public health significance. C. trachomatis invades the mucosal surface of the female genital tract consequently triggering [...]