cancer therapy – TechConnect Briefs

Overcoming Challenges in Manufacturing Scale-Up of Plasmonic Gold Nanorods: Bringing Photothermal Therapy to the Clinic.

Pagliaro L., Siva Therapeutics Inc, US

Siva Therapeutics is developing a simple, safe, and effective adjunct cancer treatment termed Targeted Hyperthermia™, which generates therapeutic heat emanating from within solid tumors using systemically injected precision gold nanorods and an infrared light engine [...]

Controlled Intracellular Release of Camptothecin by Glutathione-Driven Mechanism

Botella P., Muniesa C., Vicente V., Fabregat K., Cabrera A., Instituto de Tecnologia Quimica (UPV-CSIC), ES

Direct coupling of camptothecin (CPT) to nanoparticles is circumvented by the reduced therapeutic activity of its structure-modified derivatives. To negotiate this problem, we have developed a novel CPT nanoplatform based in a mercapto-functionalized silica hybrid [...]

Importance of Solid Lipid Nanoparticles in Cancer Therapy

Guney G., Kutlu H.M., Anadolu University, TR

A drug delivery system can be defined as a system that capable of releasing a carried bioactive agents in a specific location within the body at a specific rate. Anti- cancer drugs can be associated [...]

New Multimodal Iron Oxide Nanoparticles as Nanotools for Cancer

Benyettou F., Chebbi I., Lalatonne Y., Sainte-Catherine O., Di Benedetto M., Lecouvey M., Seksek O., Motte L., Université Paris 13, FR

The goal of this project is to elaborate new multifunctional magnetic nanovectors to vectorize biological interest molecules for therapy and diagnostic applications. Indeed, iron oxide nanoparticles, tanks to their magnetic properties, are used as contrast [...]

Chitosan Membrane in Combinations with Nanoparticles and Adriamycin as a Treatment to Inhibit Glioma Growth and Migration

Leung S.W., Gao W., Gu H., Bhushan A., Lai J.C.K., Idaho State University, US

Our previous and on-going studies indicated that U87 cells cultured on chitosan film/membrane exhibited significantly slower growth and proliferation kinetics compared to U87 cells cultured in the absence of chitosan film/membrane. Chitosan exhibits anti-microbial activities [...]

Condensation of Therapeutic Oligodeoxynucleotides and Plasmid DNA with PPI Dendrimers and PPI-Modified Gold Nanoparticles

Chen A.M., Nair S.K., Thomas T.J., Thomas T.T., Thomas T.J., Thomas T.T., He H., Rutgers Unverisity, Newark, US

We demonstrated the formation of oligonucleotide nanoparticle in the presence of polypropylenimine dendrimers using total intensity light scattering as well as AFM and TEM. Confocal microscopic analysis showed that the nanoparticles formed with G4 and [...]