AFM – Page 4 – TechConnect Briefs

Nanocomposites based on Self-assembly of Collagen with DNA

Yadavalli V.K., Pidaparti R.M., Virginia Commonwealth University, US

Collagen is a fibrous protein that undergoes a complex self-organizing process at the nano-, micro-, and macro-scales to form hierarchical fibers. Fiber nano/microstructures are extremely sensitive to biophysical/biochemical environments. Their mechanical properties and anisotropy (macroscale) [...]

Hybrid Nanoparticles Targeted by Antitumor Antibodies and Emitting Alpha-particles

Resheto I.V., Deev S.M., Chuvilin D.Y., Panchenko V.Y., Sukharev S.S., Streltsova E.A., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

We describe a new therapeutic nanoparticle’s design, which consists of three parts: targeting, effecter and linker. Targeting part: an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His5). The anti-HER2/neu mini-antibody could be used to deliver barnase to [...]

Inhibitory Effects of Gold and Silver Nanoparticles on RSV Studied by Atomic Force

Boyoglu S., Vig K., Pfendt A., Pillai S., Willing G.A., Singh S.R., Alabama State University, US

Human Respiratory Syncytial Virus (RSV) causes severe lower respiratory tract infections in infants which may progress to pneumonia. RSV accounts for approximately 4,500 deaths and 90,000 hospitalizations in infants and children in the United States [...]

Atomic Force Microscopy as a Tool for Research in Oncocytology

Reshetov I.V., Chissov V.I., Volchenco N.N., Sukharev S.S., Slavnova E.N., Ivanov Yu.S., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

Most of investigations have studied specimens prepared by complex techniques which are unusual for hospitals. In present paper Scanning Probe Microscopy (SPM) has been used for searching signs of malignancy in specimens prepared identically to [...]

Measurement of Structural and Mechanical Property of Live Mesangial Cell (MC) by Atomic Force Microscopy (AFM)

Lee G.J., Lee S-H., Park E.J., Park H.K., Park J.H., Lee G.J., Lee S-H., Lim J.E., Eo Y.H., Han J.H., Choi S., Park E.J., Park H.K., Park J.H., Shin Y.A., Jin H.S., Hong K.W., Oh B.S., Park E.J., Park H.K., Park J.H., Kyung Hee University, KR

Atomic force microscopy (AFM) has become an important device to visualize various cells and biological materials for non-invasive imaging. The major advantage of AFM compared to the conventional optical and electron microscopes is its convenience. [...]

Gold Nanoparticle-Assisted AFM Study of DNA Damage and Repair

Demir E., Ozber N., Kavakli H., Kizilel S., Rumelifeneri Yolu College of Engineering, TR

The purpose of this research is to investigate gold nanoparticles as a potential scaffold for the characterization of DNA damage and repair using atomic force microscopy techniques. The procedure consists of functionalizing the surface of [...]

In-Situ Nanomechanical-Electrical Testing of One-Dimensional Materials

Yassar R.S., Yap Y.K., Michigan Technological University, US

One-dimensional nanomaterials including nanotubes are building blocks for constructing various complex nanodevices. Boron nitride (BN) nanotubes with structure similar to carbon nanotube are known to be among the strongest insulators in the world. In this [...]

Systematic Quantitative Characterization of Surface Nanostructures

Al-Mousa A., Niemann D.L., Gunther N.G., Rahman M., Santa Clara University / PDF Solutions, US

In this paper, a systematic analysis technique is presented and applied to Atomic Force Microscopy (AFM) data. Our technique isolates surface nanostructures and extracts quantitative information such as their shape and size. Examples of features [...]

Environmental Digital Pulsed Force Mode AFM in Biomedical Coatings Research

Haugstad G., Wormuth K., University of Minnesota, US

We report ongoing methodological developments using Digital Pulsed Force Mode AFM of model coatings containing the drug dexamethasone dispersed in polylactide (biodegradable), poly(butylmethacrylate) (PBMA), and PBMA/poly(laurel methacrylate) (PLMA) blends. Studies include (1) multi-technique analyses, understanding [...]

Molecular Simulation of the Nanoscale Water Confined between an Atomic Force Microscope Tip and a Surface

Choi H.J., Kim J-Y, Hong S.D., Ha M.Y., Jang J., Pusan National University, KR

Under ambient humidity, water condenses as a meniscus between an atomic force microscope (AFM) tip and a surface, giving rise to a strong capillary force on the tip. We performed a molecular dynamics simulation of [...]