Zhou H. – TechConnect Briefs

Adhesion and Differentiation of Neuronal Cell on Photoresist Derived Carbon Substrates

Pampuro R., Chen L., Zou T., Zhou H., Worcester Polytechnic Institute, US

Cellular response to substrate topography and chemistry is a crucial aspect in guided neurite growth for application in neuroregenerative medicine. Experiments investigating cell culture on nanopatterned surfaces have elucidated the nuances of cell-substrate interaction. Among [...]

Fabrication of Nanometer-Sized Structures by C-NEMS Technology

Ma K-S, Madou M., Jia G-Y, Xu Q., Zhou H., Wang C-L, Zoval J., Madou M., University of California Irvine, US

We have demonstrated a technique to fabricate carbon nano wires of controllable dimension and location using a top-down methodology. The width and thickness of the wires are in the tens of nanometer range. Additionally, the [...]

Electrical Detection of DNA Hybridization using Adjacent Impedance Probing (AIP) Method

Zhou H., Ma K-S, Madou M., Zoval J., Madou M., University of California Irvine, US

Sensitivity and selectivity are two of the most challenging criteria for the development of DNA biosensor devices. These biosensor devices have attracted interest for the rapid identification of pathogens in humans, animals, and plants, for [...]

Nano-Lithography in Ultra-High Vacuum (UHV) for Real World Applications

Gilsinn J., Zhou H., Damazo B., Fu J., Silver R., NIST, US

As nano-lithography technology improves, more companies and research groups have the capability to create nano-scale structures. Scanning tunneling microscopes (STMs) are commonly used to create these structures and evaluate them afterward. One difficulty is that [...]

Detection of DNA Hybridyzation with Impedance Amplifying Labels

Ma K-S, Madou M., Zhou H., Fischetti A., Zoval J., Madou M., University of California Irvine, US

Traditionally used nucleic acid analysis detection platforms rely on fluorescent or radioactive labels. Optical techniques require large and expensive equipment such as automated colorimetric and fluorimetric instruments that greatly increase the cost of the whole [...]