Vorozhtsov G.N. – TechConnect Briefs

Contrasting agent for magnetic resonance imaging based on nanostructural dispersion of Manganese derivative of phthalocyanine: preliminary investigation results

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Dolotova O.V., Uchevatkin A.A., Yu. Saveliev O., Yu.Baryshnikov A., Andronova N.V., Oborotova N.A., Kaliya O.L., Pirogov Yu.A., Vorozhtsov G.N., Yu.Baryshnikov A., N.N. Blokhin Russian Cancer Research Center or RAMS, RU

Contrast agents (CA) are used to increase tumor contrasting in magnetic resonance imaging (MRI). The work is devoted to estimation of Manganese chloride tetra-3-phenylthio-tetra-5-tert-buthylphthalocyanine [3-(PhS)4-5-(t-Bu)4PcMnCl] as potential CA for MRI. We have developed the micellar [...]

Influence of liposome size on accumulation in tumor and therapeutic efficiency of liposomal near-IR photosensitizer for PDT based on aluminum hydroxide tetra-3-phenylthiophthalocyanine

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Pevgov V.G., Lukyanets E.A., Oborotova N.A., Gurevich D.G., Zorin A.A., Derkacheva V.M., Smirnova Z.S., Loschenov V.B., Vorozhtsov G.N., Baryshnikov A.Yu., A.M. Prokhorov General Physics Institute of RAS, RU

Size of nanoparticles is considered to be the one of main factors determining the efficiency of nanostructural antitumor drugs. Current work was performed to estimate the influence of liposomal size distribution on level and selectivity [...]

New efficient nanostructural near-IR photosensitizer for photodynamic therapy of malignancies based on micellar dispersion of zinc octa-4,5-decylthio-3,6-chloro-phthalocyanine

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Lukyanets E.A., Negrimovsky V.M., Barkanova S.V., Zorin A.A., Umnova L.V., Oborotova N.A., Loschenov V.B., Vorozhtsov G.N., Baryshnikov A.Yu., N.N.Blokhin Russian Cancer Research Center of RAMS, RU

The work is devoted to investigation of new nanostructural photosensitizer on a base of zinc octa-4,5-decylthio-3,6-chloro-phthalocyanine solubilized in micellar dispersion. Photosensitizer possesses its absorption maximum at about 730 nm and can be considered promising for [...]

Laser Heating of Sulphuretted Carbon Nanoparticles Inhibits Tumor Growth

Kogan B.Ya., Yakubovskaya R.I., Pankratov A.A., Andreeva T.N., Kvacheva L.D., Titov A.A., Puchnova V.A., Feysulova R.A., Vorozhtsov G.N., Organic Intermediates & Dyes Institute, RU

Light-absorbing nanoparticles incorporated in a tissue can be heated by short-pulsed laser irradiation up to several thousand Kelvin degrees. Average tissue temperature may be kept normal if the concentration of these particles is low. Antitumor [...]