Vig K. – TechConnect Briefs

Exploring Bacterial Interactions of Expanded-PTFE in the Presence of PVP-coated Silver Nanoparticles, Peptides p753 and p359 in 2D and 3D models

Finkle M., Meléndez Navarro P., Vig K., University of Nevada-Las Vegas, US

Tissue engineering is recognized as an avenue to improve treatment for various diseases. Expanded-PTFE (ePTFE) has gained popularity as a tissue scaffold to develop a vascular graft for generating blood vessels in cardiac surgeries. However, [...]

Bacteria Inhibitory Action of Peptides P753 and P359 in 2D and 3D Cell Cultures

Masuda J., Vig K., University of Hawaii at Manoa, US

The current study investigated two proprietary peptides, p359 and p753, for their antibacterial activity against Escherichia coli (E.Coli) and Staphylococcus aureus (S. aureus). Minimum Inhibitory Concentration (MIC) of bacteria for p359 and p753 was 50μg/mL [...]

Impact of Docetaxel conjugated Nanodiamonds on Gene expression of Prostate Cancer (PC3) Cells

Cedeño Ortiz J.D., Joshi S., Singh S.R., Vig K., Alabama State University, US

Prostate cancer (PC) is the second leading cause of adult male death in the United States. This type of cancer is a disease where the prostate gland cells start to grow without control, changing in [...]

miRNA Expression Analysis in HEp-2 Cells after Gold Nanorod Application

Montgomery A., Bawage S., Chaudhary A., Singh S.R., Vig K., Alabama State University, US

Gold Nanoparticles are popular because of their use in drug delivery and other biomedical applications. However, not much is known about their toxicity. The purpose of the present study was to evaluate the toxicity of [...]

Superparamagnetic Iron Oxide Nanoparticles as Drug Delivery Vehicles

Vig K., Casey K., Tiwari P.M., Miller M., Samant R., Singh S.R., Alabama State University, US

In recent years, nanotechnology has emerged as one of the most promising fields for biomedical applications and healthcare. The use of nanoparticles has earned much attention due to their small size, high surface area to [...]

Antibacterial effect of Silver Carbon Nanotubes against Multi-drug resistant Pseudomonas aeruginosa

Dosunmu E., Pillai S., Vig K., Singh S.R., Dennis V.A., Coats M., Alabama State University, US

Silver carbon nanotubes AgCNT inhibited the growth of P. aeruginosa at the lowest concentration of 60 µg/ml for at least 12 hr. Further studies of structural and morphological changes would further elucidate the mechanism of [...]

Supermagnatic Iron Oxide Nanoparticles Toxicity to Mammalian Cells

Vig K., Tiwari P., Parveen A., Rangari V., Singh S.R., Alabama State University, US

The present study investigates the development of superparamagnetic iron oxide nanoparticles as a controlled release drug formulation and use as anticancer therapeutic agents. Iron oxide nanoparticles (IONPs) were synthesized using ultrasonic irradiation of iron pentacarbonyl [...]

Inhibitory Effects of Gold and Silver Nanoparticles on RSV Studied by Atomic Force

Boyoglu S., Vig K., Pfendt A., Pillai S., Willing G.A., Singh S.R., Alabama State University, US

Human Respiratory Syncytial Virus (RSV) causes severe lower respiratory tract infections in infants which may progress to pneumonia. RSV accounts for approximately 4,500 deaths and 90,000 hospitalizations in infants and children in the United States [...]

Silver Coated Carbon Nanotubes Inhibit RSV Infection

Adiani L., Subbarayan P., Boyoglu S., Vig K., Pillai S., Rangari V., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) is a member of the genus Pneumovirus in the family of Paramyxoviridae. It is one of the most common causes of upper and lower respiratory tract infections, bronchiolitis and pneumonia worldwide [...]

Respiratory Syncytial Virus Inhibition by Gold and Titanium Nanoparticles

Vig K., Boyoglu S., Rangari V., Pillai S., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) is the leading cause of severe respiratory illnesses including bronchiolitis and pneumonia in young children. The RSV surface proteins F (fusion) and G (attachment) are major targets for vaccine development against [...]