Sukharev S.S. – TechConnect Briefs

Visualization of Thyroid Cancer Signs by Atomic Force Microscopy

Reshetov I.V., Chissov V.I., Sukharev S.S., Slavnova E.N., Volchenco N.N., Bykov V.A., P.A.Hertzen Moscow Research Oncological Institute, RU

Aim: Search for the AFM signs of the thyroid cancer. Instruments and Materials: AFM-system NTEGRA Prima, NT-MDT Co., Zelenograd, Russia. Cytological specimens prepared identically to those used in traditional cytological studies. Characteristics measured: the heights [...]

Evaluation of Tools for Nanoparticles-modulated Hyperthermia by Atomic Force Microscopy

Reshetov I.V., Chissov V.I., Sukharev S.S., Matorin O.V., Korizky A.V., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

Some of the properties of the medicinal forms and tools, supposed to be used as hyperthermia modulators, can be evaluated by the atomic force microscopy (AFM): sizes and concentration of nanoparticles, their capability for the [...]

Hybrid Nanoparticles Targeted by Antitumor Antibodies and Emitting Alpha-particles

Resheto I.V., Deev S.M., Chuvilin D.Y., Panchenko V.Y., Sukharev S.S., Streltsova E.A., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

We describe a new therapeutic nanoparticle’s design, which consists of three parts: targeting, effecter and linker. Targeting part: an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His5). The anti-HER2/neu mini-antibody could be used to deliver barnase to [...]

Atomic Force Microscopy as a Tool for Research in Oncocytology

Reshetov I.V., Chissov V.I., Volchenco N.N., Sukharev S.S., Slavnova E.N., Ivanov Yu.S., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

Most of investigations have studied specimens prepared by complex techniques which are unusual for hospitals. In present paper Scanning Probe Microscopy (SPM) has been used for searching signs of malignancy in specimens prepared identically to [...]

Influence of Nanoparticles on the Nervous Tissue Properties

Reshetov I.V., Chissov V.I., Sukharev S.S., Timoshenko V.Y., Sidletskiy V.Y., Forsh P.A., P.A.Hertzen Moscow Research Oncological Institute, RU

Interaction between the nanoparticles and nervous tissue in the process of the damage healing is the object of study in the present work. Laboratory animal (rat) was put into deep narcosis. The Nervus ischiadicus was [...]

Diffusion of Nanoparticles through the Tissues in Experiment

Reshetov I.V., Frank G.A., Sukharev S.S., Efremov G.D., Danileico Yu.C., Timoshenko V.Yu., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

We have created nanocrystals of silicon with sizes in the greatest measurement in the average 50 nm (from 4 to 100 nm), and nanocrystals of the oxide of aluminum with the adsorbed molecules of phthalocyanines, [...]

Multicomponent Coatings Improve the Biocompatibility of Load-bearing Implants

Chissov V.I., Reshetov I.V., Frank G.A., Levashov E.A., Shtansky D.V., Filushin M.M., Efremov G.D., Sukharev S.S., P.A.Hertzen Moscow Research Oncological Institute, RU

New implants are studied in vivo under the conditions, when the replaced defect is located on the bone, which accomplishes motions with the large amplitude and with the large load.Three types of implants were placed [...]

The Evolution of Vievs of in vivo Use of Nanoparticles for Tumor Treatment

Chissov V.I., Reshetov I.V., Luskinovich P.N., Shepelev A.A, Efremov G.D., Matorin O.V., Sukharev S.S., P.A.Hertsen Moscow Research Oncological Institute (MROI), RU

The methods of site-specific delivery of antitumor agents without the general and system consecuences remain to be actual because the need to reduce the negative effects of antitumor treatment. In the experiment attempts are made [...]

Reconstruction of Load-Bearing Defects in Oncology by Using Nanomodification of Implants

Chissov V.I., Reshetov I.V., Levashov E.A., Shtansky D.V., Filushin M.M., Sukharev S.S., Bashkova I.A., Moscow Research Oncological Institute, RU

By means of nanotechnological approach different coating procedures enlarging biocompatibility factors of implants were developed. The well-known materials – titanium plates are used as substrates supporting structures. Depending on the construction type (stable or rolling) [...]