Shieh M.J. – TechConnect Briefs

Gold Nanoshells With Micellar Core for The Delivery of Hydrophobic Chemotherapeutic and Cancer Photothermal Therapy

Lee S-Y, Shieh M.J., National Taiwan University, TW

Gold nanoshells have attracted great research interest because of its potential application in cancer photothermal therapy. In the present study, we established a multifunctional gold nanoshell that directly utilizing positively charged PDMA-b-PCL micelles as a [...]

Synthesis of amphiphilic block copolymers to deliver HSP90 inhibitors for colorectal tumors

Lin C.Y., Shieh M.J., National Taiwan University, TW

In this article, we present pH-sensitive and small size nanoparticles as carrier to encapsulate 17-AAG. We anticipate that this platform will provide a new strategy for cancer therapy.

Novel Photo-thermal Controlled Drug-releasing Vectors for Cancer Detection and Treatment

Tsai M-H, Ling D., Shieh M.J., National Taiwan University, TW

Cancer is always the leading cause of deaths in worldwide. The aim of this research is to develop a new generation of chemotherapeutic drugs with both photothermal activated drug release and MRI diagnostic function. Carbon [...]

Multi-functional micelles for the combination of chemotherapy and radiotherapy in hepatocellular carcinoma

Shih Y-H, Peng C.L., Luo T-Y, Shieh M.J., National Taiwan University, TW

Hepatocellular carcinoma is the third leading cause of cancer deaths in worldwide. In this study, multi-functional micelles loaded with doxorubicin (Dox) and labeled with the radionuclide rhenium-188 (188Re) were developed to provide the combination of [...]

Overcome the Doxorubicin Resistance by Multimodal Nanoparticles in Mice

Lai P.S., Hsu C.Y., Lu H.-L., Yu H.-P., Syu W.-J., Shieh M.J., National Chung Hsing University, TW

The efficacy of many chemotherapeutic agents is reduced in cells that have developed multiple drug resistance (MDR). To address this important problem, a biodegradable polymer was coupled to the photosensitizer and the resulting photosensitizer-nanoparticles were [...]

Chitosan Nanoparticle Combined with Ultrasound for Cervical Cancer Detection

Tsai K-C, Shieh M.J., Yang S.J., Lin W-L, Chen W-S, Institute of Biomedical Engineering, TW

Photodynamic medicine is a novel approach for cancer detection and treatment via different photosensitizers and suitable light source. The 5-Aminolevulinic acid (5-ALA) can be converted into protoporphyrin IX (PpIX) that can be utilized as a [...]

Colorectal Cancer Cell Detection by Chitosan Nanoparticle Conjugated with Folic Acid

Yang S.J., Chen J-W, Shieh M.J., Institute of Biomedical Engineering, TW

Endoscopy is a common diagnosis device for the detection of colorectal cancer and there are two methods to improve the diagnostic sensitivity. One is chromoendoscopy, and the other is magnifying endoscopy. Color contrast dye, such [...]

A Novel Detection of Early Colorectal Cancer by Chitosan Nanoparticles Conjugated with Folic Acid

Yang S.J., Lin F.H., Tsai K-C, Shieh M.J., Institute of Biomedical Engineering, National Taiwan University, TW

The 5-Aminolevulinic acid (5-ALA) can be converted into protoporphyrin IX (PpIX) that can be utilized as a fluorescent probe for tumor detection. In this study, folic acid was conjugated on chitosan molecules via covalent bond [...]

Synthesis and Photodynamic Efficacy of PAMAM-Photosensitiser Conjugates in Vitro

Peng C.L., Lai P.S., Lai T.-Y., Chiu C.H., Chang C-C, Lai P.S., Lai T.-Y., Shieh M.J., National Taiwan University, TW

Starburst polyamidoamine (PAMAM) dendrimer is a new class of highly branched spherical polymer. Covalent attachment of porphyrin to PAMAM dendrimer may alter the pharmacokinetics, cell targeting, and photophysical properties of photosensitizer. We investigated the uptake, [...]

Shell Cross-Linked Nanoparticle Based on Poly(e-caprolactone)-Poly(ethylene glycol) for Photosensitizer Delivery

Lai P.S., Huang M.Y., Wang S.J.J., Chen C.N., Shieh M.J., National Taiwan University, TW

Photodynamic therapy (PDT) is a novel photochemical process for producing localized tissue necrosis, which involves the activation of a photosensitizing drug in the target tissue with light of a specific wavelength matched to an absorption [...]