Sahu R. – TechConnect Briefs

The biodegradable polymeric PLA-PEG nanoparticles is an efficient delivery system for a chlamydial M278 mucosal nanovaccine that provides protective systemic and mucosal antibody responses in mice

Verma R., Sahu R., Dixit S., Singh S.R., Dennis V.A., Alabama State University, US

The rising concerns relating to the failure of public health programs, relying mostly on antibiotic treatments to control the plethora of disease manifestations caused by Chlamydia trachomatis in humans, strongly begs the urgency for an [...]

Physio-structural and immunological characterization of a PLGA 85/15 encapsulated Chlamydia recombinant MOMP nanovaccine candidate

Sahu R., Dixit S., Singh S.R., Dennis V.A., Alabama State University, US

The quest for vaccine development against Chlamydia trachomatis (CT), the leading cause of bacterial sexually transmitted diseases worldwide, has escalated to reduce its occurrence and global economic burden. Recently, nanovaccines have emerged as attractive candidates [...]

Sustained Release of Functional Interleukin-10 Encapsulated within Poly (lactic acid)-b-Poly (ethylene glycol) Nanoparticles Down-regulates Cytokines in Mouse Macrophages Exposed to Chlamydia trachomatis

Duncan S., Dixit S., Sahu R., Nyairo E., Singh S.R., Dennis V.A., Alabama State University, US

Inflammation which is induced by the presence of cytokines and chemokines is an integral part of Chlamydial infection. Chlamydia trachomatis (CT), the bacterial pathogen responsible for this sexually transmitted infection worldwide, causes severe inflammation including, [...]

PLA-PEG nanoparticles are suitable for effective maturation and uptake by dendritic cells for Chlamydia trachomatis outer membrane peptide-based vaccine

Dixit S., Sahu R., Singh S.R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is considered an important human pathogen because it is the most reported sexually transmitted bacterial infection globally. We showed that M278 (a peptide derived from the major outer membrane protein of C. trachomatis) [...]